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ThromboGenics Completes Patient Enrolment in the Phase IIb Trial of Microplasmin in Vitrectomy (MIVI III)
Date:4/1/2008

we will have further encouraging results from this trial."

About Vitrectomy

Approximately 600,000 surgical vitrectomies are performed annually worldwide. The U.S. market accounts for more than 40% of treatments, and is growing at 6-8% per year. During a vitrectomy, three incisions are made through the white of the eye; the surgeon then inserts small instruments into the eye, cuts the vitreous gel, and suctions it out. There are certain risks inherent to this surgery including bleeding, infection, increased eye pressure, retinal detachment, and development of cataracts.

As Microplasmin could induce a PVD without the need for vitrectomy, it may serve as a more convenient, less invasive treatment option for certain eye conditions. For example, results from ThromboGenics' MIVI II Traction trial, which examined the safety and efficacy of Microplasmin in the treatment of vitreomacular traction showed that Microplasmin was able to resolve vitreomacular traction and even achieve closure of some macular holes, conditions that otherwise would have required vitrectomy.

Other major eye diseases that may benefit from nonsurgical PVD induction include diabetic retinopathy and age-related macular degeneration (AMD). Diabetic retinopathy is the leading cause of blindness among working-age adults, while AMD is the leading cause of blindness among the elderly.

About ThromboGenics

ThromboGenics is a biotechnology company focused on discovery and development of biopharmaceuticals for the treatment of a range of vascular diseases. The Company has several programs in Phase II clinical development including microplasmin, which is being evaluated as a treatment for vitreoretinal disorders and as a thrombolytic agent for vascular occlusive diseases such as acute stroke. ThromboGenics is also developing novel antibody therapeutics in collaboration with BioInvent International; these include TB-402 (Anti-Factor VIII), scheduled to enter Phase II clini
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SOURCE ThromboGenics NV
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