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Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL
Date:12/9/2008

who had a grade 3 reaction.

After a median follow-up time of 37.9 months, there were 75 deaths, 56 percent due to disease progression, 31 percent due to infection, and 13 percent unrelated to CLL. ORR was 34 percent (CRR four percent, PRR 30 percent), median PFS time was 7.7 months, and median OS time was 19.1 months.

About Chronic Lymphocytic Leukemia

CLL is the most prevalent form of leukemia in adults. The disease is most commonly diagnosed among people age 50 or older and is characterized by the accumulation of functionally immature white blood cells (lymphocytes) in the bone marrow, blood, lymph tissue and other organs. Two types of lymphocytes are present in the blood, B cells and T cells. The majority of this patient population (90 percent) suffers from a subtype called B-cell chronic lymphocytic leukemia, or B-CLL. Symptoms include fatigue, bone pain, excessive sweating, abnormal bruising, and decreased appetite and weight loss. Bone marrow infiltration leads to a lack of healthy blood cells, thus leading to fatigue, susceptibility to bleeding and weakening of the immune system, exposing the patient to a higher risk of infection.

About Cytogenetic Markers

In some cases of CLL, at least one of the 23 pairs of chromosomes on a cell is found to be either deleted or part of it is lost. The most commonly seen deletions involve parts of chromosomes 13, 11 and 17. The loss of part of chromosome 13 is usually linked with a slower growing disease and a better outlook, while defects in chromosomes 11 or 17 often indicate a poorer outlook.

Cytogenetic testing evaluates chromosomes under a microscope to detect any of these abnormalities. FISH is a type of cytogenetic test that uses special fluorescent dyes that only attach to specific parts of particular chromosomes. It can be used on regular blood or bone marrow samples and is very accurate, which i
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SOURCE Bayer HealthCare Pharmaceuticals Inc.
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