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Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL
Date:12/9/2008

study, patients received doses of Campath three times per week. After a median follow-up time of 37.9 months, the study found an ORR of 34 percent, a CRR of four percent, and a PRR of 30 percent among the total patient population. Median PFS time was 7.7 months, and median OS time was 19.1 months.

"These analyses are an important step forward in the consideration of targeted therapies for treating high-risk CLL," said Pam Cyrus, vice president, Medical Affairs, Oncology, Bayer HealthCare Pharmaceuticals. "We remain committed to determining the best treatment regimen for all patients with CLL, including this high-risk patient population."

CLL is characterized by the accumulation of functionally immature white blood cells (lymphocytes) in the bone marrow, blood, lymph tissue and other organs. Roughly 90,000 people in the United States are living with CLL, according to the Leukemia and Lymphoma Society. More people are living with CLL than any other type of leukemia, and most people with CLL are at least 50 years old.

About the Studies

Abstract #3164

Clinical Outcome of B-Cell Chronic Lymphocytic Leukemia Following Alemtuzumab Therapy: Retrospective Study within Various Cytogenetic Risk Categories

Using the largest database of efficacy analysis of Campath in CLL, researchers identified 138 CLL patients (73 male, 65 female, with a median age of 64 years) stratified according to cytogenetic markers that were identified by fluorescent in situ hybridization (FISH) testing. The median number of two prior therapies in this group was two (range, 0 - 10), and of the patients who received prior treatment with fludarabine (n=113), 70 percent were refractory to the fludarabine treatment, 25 percent sensitive, and in five percent this was unknown. Responses were evaluated according to the National Cancer Institute (NCI) criteria, and researchers also asse
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SOURCE Bayer HealthCare Pharmaceuticals Inc.
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