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Three Clinical Studies of bioTheranostics Molecular Breast Cancer Diagnostics Presented at San Antonio Breast Cancer Symposium
Date:12/14/2008

rence is 'low' or 'high'," said Dr. Sgroi. "The ability to reduce the number of patients in the 'intermediate' group by reclassifying them as either 'high' or 'low' risk, making risk prediction more specific, should go a long way in helping medical professionals select the most appropriate therapy for each of their patients."

On Saturday, Matthew Goetz, M.D., from Mayo Clinic and colleagues from Austria presented data examining the predictive utility of CYP2D6 and the prognostic utility of the Theros Breast Cancer Index in women with breast cancer randomized to receive five years of treatment with tamoxifen or two years of tamoxifen followed by three years anastrozole treatment. The researchers found that the Theros Breast Cancer Index will identify, among patients with early stage breast cancer, those with a higher risk of treatment failure when treated only with hormonal therapy. They concluded that the Theros Breast Cancer Index identified approximately 25 percent of grade 1 and grade 2 breast cancers that had a nearly three-fold higher risk for a subsequent recurrence in distant organs.

Finally, data from a study presented on Sunday by Olle Stal, PhD, and colleagues from Linkoping University in Sweden explored the value of the HOXB13 gene in predicting benefit of tamoxifen therapy. Researchers reviewed HOXB13 protein expression in tumor samples from 866 patients with estrogen- receptor positive tumors. Patients whose tumors expressed no or low levels of HOXB13 had a clear benefit from tamoxifen in terms of longer distant recurrence-free survival. Patients with a high or intermediate HOXB13 expression did not experience a distant recurrence-free survival benefit from tamoxifen as compared to untreated patients.

"Data from these studies reinforce clinical and research experience to date which has shown that the Theros Breast Cancer Index is an excellent test for assessing breast cancer risk prognosi
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