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Three Clinical Presentations on Tapentadol Extended Release Tablets for Chronic Pain Featured at 2009 American Pain Society Annual Meeting
Date:5/7/2009

Safety and Efficacy Data from Phase 3 Study will be Highlighted

SAN DIEGO, May 7 /PRNewswire-USNewswire/ -- Chronic pain is a significant medical challenge in the United States, and chronic low back pain is the most common cause of disability in developed countries. An estimated 100 million Americans suffer from chronic pain each year. If left undertreated, chronic pain can impair an individual's ability to carry out daily activities and diminish quality of life.

Three clinical presentations about the use of tapentadol extended release tablets to treat patients with chronic low back pain, including pivotal Phase 3 safety, efficacy and gastrointestinal tolerability data, will be discussed during the poster sessions of the 28th Annual Scientific Meeting of the American Pain Society (APS) in San Diego, California on Thursday, May 7, and Friday, May 8, 2009. These data presentations are supported by Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (J&JPRD).

Tapentadol binds to mu-opioid receptors and inhibits norepinephrine re-uptake. Although the exact mechanism of action is not known, these two mechanisms, which affect established pain pathways, are thought to be responsible for pain relief with tapentadol. The U.S. Drug Enforcement Agency has proposed placing the tapentadol molecule into Schedule II of the Controlled Substances Act.

J&JPRD continues to study tapentadol extended release formulation for chronic pain, and a New Drug Application (NDA) is planned for submission to the United States Food and Drug Administration (FDA) this year. The NDA filing is part of the ongoing commitment of J&JPRD and PriCara(R), Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc., to bring new and innovative products to patients and physicians for the treatment and management of pain.

The following posters on tapentadol extended release data will
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SOURCE Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
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