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Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
Date:8/19/2007

rgestrel and ethinyl estradiol in a daily oral tablet which eliminates the menstrual cycle and is being trialed as a potential treatment for severe premenstrual syndromes.

Third is a drug launched in Japan in June 2007 for the treatment of incontinence and pollakiuria (frequent urination) under the name Staybla(R). Urinary incontinence is particularly prevalent in men and usually associated with aging. Where the problem is an overactive bladder, patients may benefit from the M1 and M3 muscarinic receptor imidafenacin, developed by Kyorin Pharmaceutical, Ono Pharmaceutical and LG Life Sciences.

Fourth is a drug for one of the most severe forms of epilepsy (Lennox- Gastaut Syndrome or LGS), affecting approximately 5% of the children who have the disease. Eisai's rufinamide, licensed from Novartis, is the first drug approved in the EU specifically for LGS. Eisai launched rufinamide in Germany, Australia and Scandinavia in June 2007 under the name Inovelon(TM). US filing is in process.

Finally for this section this quarter, Torisel(TM) is the brand name of temsirolimus, an analog of the mTOR inhibitor sirolimus (rapamycin) developed by Wyeth Research for the oral treatment of advanced renal cell carcinoma (RRC). Having received FDA approval in May 2007, the drug is now available to patients in the US, while approval is pending in the EU.

Following are the top five drugs in each category of phase changes:

The Five Most Promising Drugs Entering Phase III Trials

- trazodone, (Depression), Labopharm

- pimavanserin, (Schizophrenia), ACADIA Pharmaceuticals

- salmon calcitonin, (Osteoporosis/Paget's disease), Novartis/Nordic

Bioscience

- Generx(TM), (Coronary artery disease), Cardium Therapeutics

- fenofibrate and pravastatin, (Mixed dyslipidemia), Sciele

Pharma/Galephar PR

The Five Most Promising Drugs Entering Phase II Trials

- VSF-173, (Excessive sleepiness), Vanda Pharmaceuticals

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SOURCE Thomson Scientific

Copyright©2007 PR Newswire.

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