Navigation Links
Third Pivotal Phase 3 Study for NicOx' Naproxcinod Shows Positive Efficacy, Safety and Blood Pressure Results
Date:11/24/2008

s clearly support naproxcinod's non-detrimental blood pressure profile

The blood pressure data for naproxcinod 750 mg bid were consistent with those obtained in the 301 and 302 studies. Blood pressure was measured using standardized and controlled office blood pressure measurements (OBPM) at baseline and at weeks 2, 6 and 13 (see NOTE). At all time points, the patients treated with naproxcinod 750 mg bid showed a very similar blood pressure profile to those on placebo. In addition, naproxcinod 750 mg bid showed a clear reduction in systolic and diastolic blood pressure (SBP and DBP) compared to naproxen 500 mg bid at all time points. No stand alone statistical analysis of the blood pressure data from the 303 study was pre-specified.

As planned, NicOx will pool the blood pressure data from the three phase 3 studies (301, 302 and 303) according to a prospectively designed protocol that has been submitted to the FDA. The Company will disclose the top-line results of the pre-specified statistical analysis on the pooled data in the coming weeks.

Naproxcinod and placebo show the same gastrointestinal (GI) adverse event rate

Naproxcinod 750 mg bid showed good overall safety and tolerability. The percentage of patients who experienced one or more GI adverse events was the same for placebo and naproxcinod 750 mg bid at 15.5%, compared to 19.2% for naproxen 500 mg bid. In terms of the percentage of patients who experienced at least one adverse event overall, this was lower for naproxcinod 750 mg than naproxen 500 mg bid. There was not a single serious cardiovascular or serious GI adverse event in the naproxcinod arm during the 13 weeks of the 303 study, in contrast to the placebo and naproxen 500 mg bid arms.

Pascal Pfister MD, Chief Scientific Officer and Head of Research and Development at NicOx, commented: "We believe these are extremely good results, with naproxcinod demonstrating cl
'/>"/>

SOURCE NicOx
Copyright©2008 PR Newswire.
All rights reserved

13611

GOOD

Page: 1 2 3 4 5

Related medicine technology :

1. Over $10 Million of CSL Behrings Privigen Was Sold in the U.S. During the Third Quarter of 2008
2. SCOLR Pharma, Inc. Reports Third Quarter 2008 Financial Results
3. Cadence Pharmaceuticals Reports Third Quarter 2008 Financial Results and Provides Clinical Development Programs Update
4. CuraGen to Host Conference Call and Webcast to Discuss Third Quarter 2008 Financial Results and CR011-vcMMAE Phase II Trial Results on November 3, 2008
5. Boston Scientific Completes Clinical Trial Enrollment for Third-Generation Drug-Eluting Stent
6. Physicians Estimate That if Approved, Ceftobiprole Will Steal Nearly a Third of Zyvoxs Patient Share in the Treatment of Nosocomial Pneumonia
7. NewCardio Announces Positive Results From Third Clinical Validation Study
8. Transcept Pharmaceuticals Announces Intent to Submit New Drug Application for Intermezzo(R) in Third Quarter 2008
9. NicOx Completes Patient Enrollment in Third Naproxcinod Pivotal Phase 3 Study
10. NeoStem Reports Positive Stem Cell Industry Research Trends From The Journal of the American Medical Association and Third Annual Stem Cell Summit
11. Tengion Launches Third Phase 2 Clinical Trial of Regenerated Human Bladder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... , Dec. 22, 2014  ConvaTec, a privately-held ... Moraviec has been appointed Interim Chief Executive Officer of ... Moraviec succeeds Ken Berger .  "The Board of ... in leading ConvaTec over the past three years," said ... of Directors.  "We are confident that the company is ...
(Date:12/22/2014)... , Dec. 22, 2014 /PRNewswire/ -- RXi Pharmaceuticals Corporation ... focused on discovering, developing and commercializing innovative therapies ... today issued the following open letter to shareholders ... Dr. Med. Sc. Dear RXi Shareholders, ... number of inaccurate statements posted on certain social ...
(Date:12/22/2014)... SAN DIEGO , Dec. 22, 2014  Pfenex ... Px563L, Pfenex,s recombinant anthrax vaccine, has been filed and ... additional funding provided by the Department of Health and ... Development Authority (BARDA). "We are extremely pleased ... anthrax vaccine, Px563L.  This represents a significant milestone in ...
Breaking Medicine Technology:ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2RXi Pharmaceuticals Issues Open Letter to Shareholders 2RXi Pharmaceuticals Issues Open Letter to Shareholders 3RXi Pharmaceuticals Issues Open Letter to Shareholders 4RXi Pharmaceuticals Issues Open Letter to Shareholders 5RXi Pharmaceuticals Issues Open Letter to Shareholders 6Pfenex Announces Active IND and Additional BARDA Funding for Recombinant Anthrax Vaccine Program, Px563L 2Pfenex Announces Active IND and Additional BARDA Funding for Recombinant Anthrax Vaccine Program, Px563L 3
(Date:12/22/2014)... 2014 Physicians in China are most ... treatment of non-Hodgkin’s lymphoma (NHL), according to a new ... healthcare consulting firm. MabThera is the only biologic available ... common form of NHL. , According to Kantar Health’s ... incidence of NHL in China has been growing and ...
(Date:12/22/2014)... December 22, 2014 Give a loved ... the gift of health and vitality. , For a ... three top-selling anti-aging formulas in special Holiday Wellness gift ... delivery. , Each bottle contains cutting-edge, proven nutritional ... don't work as well as we age. ...
(Date:12/22/2014)... 7,178 small business owners and marketing professionals avoided ... opted instead to join Digital Marketer, an Austin, Texas ... annual “Black Friday Boot Camp”. , ... 5 hour online training event and raised $50,000 in ... Central Texas based charities dedicated to fighting childhood cancer. ...
(Date:12/22/2014)... NAPW honors Cheryl ... the Year. She is recognized with this prestigious distinction ... networking organization of professional women in the country, spanning ... Professional Women is a vibrant networking community with over ... Kreider is passionate and committed to best practices that ...
(Date:12/21/2014)... 22, 2014 In this report, ... by power source, product, and application. The market, ... and pneumatic instruments. By product, the market covers ... segments. The handpieces market is further subdivided into ... coagulators, laparoscopic instruments, shavers, wire/pin drivers, and others. ...
Breaking Medicine News(10 mins):Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 3Health News:You Still Have Time to Give the Gift of Health and Vitality to a Mature Loved One 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 3Health News:National Association of Professional Women Announces Cheryl A. Kreider, President / CEO of Kreider Health Solutions, LLC, a 2014 Professional Woman of the Year 2Health News:Global Powered Surgical Instruments Market Hit to $2.1 billion by 2019 - New Research Report by MarketsandMarkets 2Health News:Global Powered Surgical Instruments Market Hit to $2.1 billion by 2019 - New Research Report by MarketsandMarkets 3Health News:Global Powered Surgical Instruments Market Hit to $2.1 billion by 2019 - New Research Report by MarketsandMarkets 4
... on a massive immunization drive aimed at protecting millions of ... nearly 10% of the// children could die in the face ... conducting the MMR (measles, mumps and rubella) immunization campaign which ... by the European Commission. ,The World Health Organization ...
... that there has been a tremendous increase in the number of ... major strain on the already burdened health system. ,According ... climb at the rate of 45% which will overtake the even ... 100,000 in the Asian region. It is the European countries which ...
... in Canada’s hospitals has improved, but targets for some ... released by Wait Time Alliance of the Canadian Medical ... information to patients about exact treatment times, especially for ... keep up the target, which is good news. Nearly ...
... up fast with the third world whether it is infant ... it was reported that Galway, the third largest city in ... taking ill because of water contamination. ,Now the ... that raw sewage has been pouring into the river Forth, ...
... from Canadian experts show that the country will soon become ... Statistics Canada warned// Tuesday that Canada would have to rely ... Canada’s aging workforce puts up their legs. , ... Canada. What distinguishes Canada is the relatively large size of ...
... more than a fad. The technology, which does away with ... to a socket to access// Internet, has spread to half ... schools across the UK. , Meanwhile, there has ... Teachers Union are asking for these wireless network communications to ...
Cached Medicine News:Health News:Cancer Time Bomb Threatening Economic Infrastructure 2Health News:Sewage Swamps River in Scotland 2Health News:Statisticians Alarmed As Canada Zooms Towards Labour Shortage 2Health News:Wire-Free – Handcuffing Good Healt 2
... Centuries of German Craftsmanship ... surgical instrumentation in the ... them available to you! ... coveted Meisterbrief certificate, which ...
... Centuries of German Craftsmanship ... surgical instrumentation in the ... them available to you! ... coveted Meisterbrief certificate, which ...
Protects the eye from symptoms caused by "dry eye, medical conditions, drug reactions and environmental factors. Forms a moisture chamber over the eye area during rest....
... Medtronic Ophthalmics offers the most ... specialty Eraser Instruments for Cataract incision, ... and discrete coagulation is achieved with ... cellular necrosis. Straight eraser styles are ...
Medicine Products: