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Third Clinical Study Confirms Treatment Guided By GeneSight Psychiatric Pharmacogenomics Test
Date:12/5/2013

sive symptoms over the 10 week trial period.  In contrast, the GeneSight group showed improved outcomes overall compared to current standard of care and greatest improvement in the 30% of patients previously taking genetically discordant medications. Based on objective genomic data, physicians for 100% of patients in the GeneSight-guided group used the report to either switch participants off medications discordant with their genetics to medications in the green bin or to adjust medication dosages versus only 50% of the physicians providing the typical standard of care.

"To my knowledge, this is the first real-world, double blind randomized control trial for pharmacogenomic intervention in psychiatry, making it an invaluable addition to the psychiatric literature," said Joel G. Winner, M.D., Medical Director at Assurex Health.  "The data in this paper align with our previous two published trials which show a doubling of response rate for major depressive disorder when the clinician uses GeneSight compared to those who did not use this integrated pharmacogenomic information."

"The Pine Rest RCT replicated and reaffirmed the clinical validity of GeneSight by prospectively categorizing and predicting which patients receiving current standard of care would have high, medium or low response to treatment using our patented combinatorial pharmacogenomic GeneSight test and actionable green, yellow and red medication stratification report," according to Bryan M. Dechairo, Ph.D., Senior Vice President, Medical Affairs & Clinical Development at Assurex Health.

These findings replicate results observed in two previous prospective joint clinical studies from Assurex Health and Mayo Clinic: the La Crosse Study published in Pharmacogenetics and Genomics (July 24, 2013) and the Hamm Study published in Translational Psychiatry (October
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SOURCE Assurex Health
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