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Third Clinical Study Confirms Treatment Guided By GeneSight Psychiatric Pharmacogenomics Test
Date:12/5/2013

MASON, Ohio, Dec. 5, 2013 /PRNewswire/ -- Assurex Health, a leading personalized medicine company, announced today the publication of a third clinical study providing evidence for the effectiveness of the GeneSight combinatorial pharmacogenomic test over the current method for selecting psychotropic medications.  The study results were published in the November 2013 issue of Discovery Medicine. Consistent with two previous clinical trials, the Pine Rest study concluded that patients are more than twice as likely to respond when treatment is guided by GeneSight compared to treatment as usual.  Importantly, GeneSight also identified 30% of patients with severe gene-drug interactions who had the greatest improvement in depressive symptoms when switched to medications concordant with their genetic profile. 

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The Pine Rest study was a prospective, double-blinded, randomized control trial (RCT) of antidepressant treatment response in subjects with a primary diagnosis of major depressive disorder followed over 10 weeks.  Patients were blinded to their treatment group and depression severity was assessed by blinded study raters.  Clinicians of patients in the guided group received the GeneSight report that categorizes psychotropic medications within a green, yellow or red "bin" based on the relationship of each medication to the patient's combinatorial gene profile.

Patients in the pharmacogenomic-informed GeneSight group showed a greater than 2-fold likelihood of response and remission as compared with the treatment as usual (TAU) group who did not have the benefit of GeneSight results.  Furthermore, 30% of patients in the TAU group were prescribed genetically discordant "red bin" medications.  This group showed less than 1% improvement in depres
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SOURCE Assurex Health
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