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TheraQuest Unveils New Pain Management Product Pipeline
Date:6/22/2010

ower abuse potential than oxycodone, oxymorphone, morphine and hydromorphone, the C-II opioids in OxyContin®, Opana® ER, Embeda® and Exalgo®.

Pain Pipeline Details

TQ-1020 (Levorphanol Extended Release)

TQ-1020 is a proprietary once-a-day extended release dosage form of the opioid analgesic levorphanol in an abuse deterrent drug delivery system (Levorphanol ER). It has activity at both opioid and non-opioid receptors, thus providing unique pharmacologic advantages over currently marketed strong opioids. Levorphanol is significantly more potent than morphine at the mu, delta and kappa opioid receptor.

Unlike OxyContin, Opana ER, Embeda and Exalgo, Levorphanol's norepinephrine and serotonin reuptake inhibition is comparable to tapentadol (Nucynta) and tramadol (Ultram ER). Consequently, levorphanol ER targets both opioid modulated ascending pathways and norepinephrine modulated descending pathways of pain in one centrally acting analgesic. Levorphanol also exerts NMDA antagonism which may partly explain its efficacy in neuropathic pain and its ability to reverse tolerance to morphine.

Levorphanol ER is being developed for chronic moderate to severe pain. It will compete in the same opioid market segment as OxyContin, Opana ER, Embeda and Exalgo (2009 U.S. opioid sales $8.5 billion).

TQ-1021 (Topical Mepivacaine)

TQ-1021 is a proprietary topical dosage form of the local anesthetic, mepivacaine for the treatment of neuropathic pain states such as painful diabetic neuropathy, postherpetic neuralgia and painful HIV-associated neuropathy. TQ-1021 has been granted Orphan Drug Designations by the FDA for the treatment of postherpetic neuralgia and painful HIV neuropa
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SOURCE TheraQuest Biosciences, Inc.
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