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The SFJ Pharmaceuticals Group Announces Agreement With Pfizer to Co-develop Dacomitinib as First-Line Treatment for Patients With Advanced Non-small Cell Lung Cancer
Date:9/7/2012

s to advance our clinical development programs and deliver new cancer medicines to patients as efficiently as possible around the world," said Garry Nicholson, president and general manager, Pfizer Oncology. "Non-small cell lung cancer remains a difficult disease to treat despite recent advances, and Pfizer is evaluating dacomitinib in NSCLC across lines of therapy and a range of histologies and molecular subtypes.  By collaborating with SFJ on the continued clinical development of dacomitinib in this patient population, we hope to more immediately bring a new first-line therapy to patients in need."

Dacomitinib is an oral, once-daily, small molecule inhibitor of HER-1 (EGFR), HER-2 and HER-4 tyrosine kinases.  It is being evaluated by Pfizer in a comprehensive clinical development program that includes two global, randomized Phase 3 clinical trials investigating its safety and efficacy as a second-line and refractory treatment for NSCLC.  Dacomitinib has not been approved by any regulatory agency.  

About the SFJ Pharmaceuticals Group
The SFJ Pharmaceuticals Group, which was formed in January of 2009 is a global drug development group of companies, which provides a unique co-development partnering model for some of the world's top pharmaceutical and biotechnology companies.  SFJ uses its financial strength and core team of pharmaceutical development experts to provide highly customized partnering models in which SFJ provides the funding and clinical development supervision, necessary to obtain regulatory approval for some of the most promising drug development programs of Pharmaceutical and Biotechnology companies. SFJ is backed by Abingworth, Clarus and Fintech, which are venture capital firms specializing in bio-pharmaceutical development. Collectively these venture capital firms manage over USD $2.5 billion in funding.

http://www.abingworth.com


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