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The New England Journal of Medicine Publishes First Clinical Results for MedImmune's Chitinase-like Protein YKL-40 in Patients With Asthma
Date:11/14/2007

001). In this cohort, the median level of tissue cells expressing YKL-40 in the lungs correlated positively with asthma severity in all patients studied (P=0.003). The median number of YKL-40 expressing tissue cells were 13.7 per millimeter squared for those with mild disease (interquartile range 3.0-28.3), 11.3 per millimeter squared for those with moderate disease (7.9-17.5), and 23.1 per millimeter squared for those with severe asthma (15.2-54.1), compared to 3.1 per millimeter squared for those without disease (2.1-7.4). There was a significant correlation between SBM thickness and the serum YKL-40 levels (r=0.51, P=0.003). Median SBM was thicker in patients with mild 9.4 microM (interquartile range 7.0-10.9) and moderate asthma 9.2 microM (8.8-10.80) compared to those without disease 4.7 microM (3.9-4.9, P<0.001) and were highest in patients with severe asthma 12.4 microM (11.5-13.4, P=0.003).

In all three cohorts, levels of circulating YKL-40 correlated to asthma severity. In the Yale cohort, median YKL-40 levels were 49.11 ng/ml (interquartile range 36.7-94.2) in patients with mild asthma, 68.43 ng/ml (38.0-88.0) in those with moderate asthma, and 77.0 ng/ml (44.6-158.4) in patients with severe asthma. (P for trend = 0.003). In the Paris cohort, median levels were 45.5 ng/ml (24.5-78.5) in patients with mild asthma, 41.0 ng/ml (25.0-67.0) in those with moderate asthma, and 94.0 ng/ml (72.0-181.5) in severe asthmatics (P for trend = 0.007). In the Wisconsin cohort, media levels were 49.11 ng/ml (36.7 - 94.2) in patients with mild asthma, 68.43 ng/ml (38.0 - 88.0) in those with moderate asthma, and 77.0 ng/ml (44.6 - 158.4) in severe asthmatics (P for trend < 0.05). Additionally, serum YKL-40 levels correlated inversely with pulmonary function in all three cohorts. YKL- 40 levels correlated inversely with FEV1 (Yale, r= -0.22, P=0.01; Wisconsin, r= -0.33, P=0.009; and Paris, r= -0.21, P=0.005).

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SOURCE MedImmune, Inc.
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