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The New England Journal of Medicine Publishes First Clinical Results for MedImmune's Chitinase-like Protein YKL-40 in Patients With Asthma
Date:11/14/2007

molecule," said Marina Pretolani, Ph, D., Inserm Unit 700 and Denis Diderot Faculty of Medicine, University of Paris 7. "Importantly, elevated expression of YKL-40 in serum and lung is associated with the degree airflow obstruction, the main hallmark of asthma severity. Finally, YKL-40 overexpression occurs in patients taking high-dose, long-term inhaled corticosteroids, suggesting that YKL-40 production is refractory to current asthma treatments and, therefore, it may represent an alternative therapeutic target for severe asthma."

Data demonstrate that serum YKL-40 levels were significantly elevated in patients with severe asthma compared to the control group. In the Yale cohort, median levels of YKL-40 in the serum from patients with asthma were 69.7 ng/ml compared to 58.3 ng/ml in those without asthma (P=0.02). Interquartile ranges were 40.0-107.1 and 40.0-73.3, respectively. Findings in the Yale cohort were subsequently confirmed in the Paris cohort. Median levels of YKL-40 in the serum from patients with asthma were 97.7 ng/ml compared to 41.5 ng/ml in those without asthma (P=0.002). Interquartile ranges were 26.8-103.5 and 11.5-57.8, respectively. Additionally, according to bronchial biopsies taken in the Paris cohort, the expression of YKL-40 was 16.2 positive cells per millimeter squared compared to 3.1 positive cells per millimeter squared (P=0.005) with interquartile ranges of 9.1-30.2 and 2.1- 7.4, respectively.

Compared to the control group, the results suggest that among patients with asthma, serum YKL-40 levels may be associated with asthma severity, and inversely with lung function. To determine this potential correlation, investigators evaluated the expression of YKL-40 in tissue cells, thickness of sub-epithelial basement membrane (SBM), levels of circulating YKL-40 in the lungs, and pulmonary function.

According to bronchial biopsies taken in the Paris cohort, lung YKL-40 levels correlated with serum YKL-40 levels (r=0.548, P < 0.
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SOURCE MedImmune, Inc.
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