The New England Journal of Medicine Publishes First Clinical Results for MedImmune's Chitinase-like Protein YKL-40 in Patients W...(a. Additionally a post-hocanalysis sugge...),Health

Date:11/14/2007

a. Additionally, a post-hoc analysis suggested that among patients with severe asthma, YKL-40 levels correlated with clinical measurements associated with severe disease, including the frequency of corticosteroid tapers, doses of oral corticosteroids and the frequency of rescue inhaler use. Investigators concluded that YKL-40 may play an important role in the pathobiology of severe asthma, warranting further study of this molecule as a potential novel pathway to disease.

"We hope that these results may encourage prospective studies to gain greater understanding of how YKL-40 levels are associated with disease activity, and the potential of this protein as a biologic target for asthma management and research," said Geoffrey Chupp, lead investigator, section of pulmonary and critical care medicine and department of internal medicine, Yale University School of Medicine. "While additional data are needed to support these findings, at this stage, we believe the results demonstrate that the biology of YKL-40 should be incorporated into the understanding of asthma pathobiology."

In the study of 253 adult patients, investigators evaluated serum levels of YKL-40 across three asthma and control cohorts. Based on an exploratory analysis of serum samples of an established cohort of subjects from Yale University (n=135), samples were then evaluated from sets of patients at the University of Wisconsin (n=66) and the University of Paris (n=52). Levels of circulating YKL-40 were measured across all cohorts, and findings were correlated with asthma severity, airway expression of the molecule and parameters of airway remodeling. Additionally, the expression of YKL-40 in the airway and its relationship to serum levels of the molecule was evaluated in the Paris cohort alone.

"The number of cells expressing YKL-40 observed in the lung was significantly increased among patients with asthma compared to the control group and correlated positively with serum levels of the
'/>"/>

SOURCE MedImmune, Inc. Copyright©2007 PR Newswire. All rights reserved

0 GOOD

Page: 1 2 3 4 5
Related medicine technology :

1. Results from Study Evaluating PROCRIT(R) in Intensive Care Unit Patients Published in New England Journal of Medicine
2. Vaccine Study in New England Journal of Medicine Wrong in Concluding Mercury Exposures are Harmless, States SafeMinds
3. Studies Showing Significant Survival Improvement with Taxotere(R)-based Regimens in the Induction Treatment of Patients with Locally Advanced Head and Neck Cancer are Published in the Same Issue of the New England Journal of Medicine
4. Paper in International Journal of Oncology Reports Alfacells ONCONASE(R) Suppresses Intracellular Oxidative Stress
5. Adlyfe Study on the Detection of Misfolded Proteins Published in the Journal Transfusion
6. Nebivolol Lowers Blood Pressure in Mild-to-Moderate Hypertensive Patients as Demonstrated in a Study Published in the Journal of Clinical Hypertension
7. Hypertension: Journal of the American Heart Association Rapid Access Reports: Hispanics Hypertension Better Controlled With Equal Access to Care
8. Risks Associated With Face Transplants May Be Lower Than Previously Thought, ASPS Journal Review Suggests
9. Nebivolol Lowers Blood Pressure in African Americans With Stage I-II Hypertension as Demonstrated in a Study Published in the Journal of Clinical Hypertension
10. UPDATE: Nebivolol Lowers Blood Pressure in African Americans With Stage I-II Hypertension as Demonstrated in a Study Published in the Journal of Clinical Hypertension
11. AIDS Healthcare Foundation Names Homayoon Khanlou, M.D. as its Chief of Medicine, U.S.