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The Leukemia & Lymphoma Society and the Knight Cancer Institute Launch Groundbreaking Collaboration to Improve Outcomes for Acute Myeloid Leukemia Patients
Date:9/17/2013

irst of its kind in the cancer space and unprecedented in terms of the range of expertise involved," said Brian Druker, M.D., director of the Knight Cancer Institute at OHSU. "We are setting ambitious milestones with the goal of helping patients. The project also might help accelerate other cancer research by serving as a model for the types of collaboration that are possible to advance research."

The project will be led by Druker and includes researchers at Stanford University, UT Southwestern Medical Center and Huntsman Cancer Institute at the University of Utah. Intel Corporation is providing computational analysis and Illumina is providing the genetic sequencing expertise. The three-year project also seeks to add more collaborators, including additional pharmaceutical and biotech companies to test a comprehensive offering of novel drugs that will address the underlying molecular complexity of AML. As part of this effort, Array BioPharma will be the first biopharmaceutical company to evaluate its therapeutics with this project.

Beat AML will create a profile of the possible genetic drivers of AML by conducting a deep genomic sequencing analysis of participating AML patients' samples. As information is gathered on potentially relevant mutations, researchers will simultaneously test the response of patients' leukemia cells to different drugs and combinations of drugs. This dual process will better equip scientists to confirm that they have correctly identified a genetic driver of the disease.  This type of approach not only speeds progress in understanding AML, but more efficiently determines ways to stop the disease and better block potential recurrence.

LLS has committed to investing more than $8.2 million in the initial three-year project which will analyze samples of cancerous cells from 900 patients with AML. The volume of samples analyzed and the level of detail collected will enable the Beat AML team to
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SOURCE The Leukemia & Lymphoma Society
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