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The Launch of Three New Parkinson's Disease Therapies Through 2015 Will Help Offset Market Losses Resulting from the Growing Impact of Generics
Date:7/30/2013

launch in Japan.

The findings also reveal that the launch of three emerging therapies through 2015 will provide useful treatment alternatives in PD. Impax Laboratories' Rytary, a reformulation of levodopa (multiple brands, generics), is expected to be prescribed, at least initially, in more-advanced patients experiencing periods of "off" time but will compete with established levodopa-adjunct therapies including the catechol-O-methyltransferase inhibitor entacapone (Novartis/Orion Pharma's Comtan/Stalevo, other brands, generics). Third-to-market monoamine oxidase-B inhibitor safinamide (Newron Pharmaceuticals/Zambon Pharma/Meiji Seika Pharma) has proved effective both in early PD and as an adjunct to levodopa in more advanced patients but will contend with the class leader rasagiline (Teva/Lundbeck's Azilect). Lastly, Acadia Pharmaceuticals' inverse agonist of 5-HT2A receptors pimavanserin is poised to become the first therapy approved specifically to treat psychotic symptoms associated with PD (a key comorbidity), but will likely compete with current antipsychotic agents that are used off-label with some clinical success today. All three of these emerging agents will face intensifying competition from generic alternatives within their respective market segments.

"The late-stage PD therapy pipeline is populated with a range of symptomatic agents targeting niche populations, but, as such, these products may have more-restricted commercial potential," said Decision Resources Senior Business Insights Analyst Nadja Rozovsky, Ph.D. "Delaying disease progression remains the greatest unmet need in the treatment of PD, but it is one that is still far from realization."

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Decision Resources (www.decisionresources.com) is a world leader in market research publications, advisory services and consulting designed t
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