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The Largest Ever Study of Diabetes Shows Intensive Glucose Control Reduces Serious Complications
Date:6/6/2008

hatsoever of any increased risk of death among those receiving intensive treatment in ADVANCE."

ADVANCE was initiated and designed by physicians at Australia's George Institute for International Health and involved a group of independent medical researchers from 20 countries worldwide. The study involved 11,140 patients with type 2 diabetes who were treated and followed up for five years. The study aimed to reduce levels of haemoglobin A1c to 6.5% or below. Intensive treatment included the sulfonylurea, modified-release gliclazide, for all patients and other drugs as required to achieve the haemoglobin target.

The major findings of ADVANCE show that intensive blood glucose lowering treatment:

- Safely controlled blood glucose to a mean HbA1c level of 6.5%

- Significantly reduced the overall risk of serious diabetes

complications (by 10%), with a one-fifth reduction in kidney disease

(21%) and 30% reduction in the development of proteinuria, a well

established marker of increased cardiovascular risk.

- Achieved a positive trend towards reduction in the risk of

cardiovascular death (12%), although not statistically significant.

"Today, it is clear that the prevention of major vascular complications of diabetes requires a multi-factorial approach addressing all modifiable risk factors," concluded Professor John Chalmers, chairman of the study management group, "among which an intensive glucose control plays an important role, in particular in protecting the kidneys."

http://www.advance-trial.com


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