Navigation Links
The Journal of Clinical Oncology Publishes Phase 3 XGEVA™ (Denosumab) Results in Advanced Cancer Patients With Solid Tumors or Multiple Myeloma
Date:2/22/2011

THOUSAND OAKS, Calif., Feb. 22, 2011 /PRNewswire/ -- Amgen (Nasdaq: AMGN) today announced the publication of results from a pivotal Phase 3 study of 1,776 advanced cancer patients with different types of solid tumors (not including breast and prostate cancer) or multiple myeloma, which compared XGEVA™ (denosumab) to Zometa® (zoledronic acid) in preventing skeletal-related events (SREs). The study, which appeared today in the Journal of Clinical Oncology, found that XGEVA was non-inferior to Zometa in delaying or preventing SREs.

"Almost every type of cancer has the potential to spread to the bone, putting patients at risk for devastating bone complications, like fracture or compression of the spinal cord," said David H. Henry, M.D., clinical professor of medicine, Pennsylvania Hospital, Philadelphia, PA. "Once a patient has bone metastases one of our major goals is to prevent events like fracture or spinal cord compression. XGEVA is an important new option to help prevent these debilitating complications."

XGEVA, the first and only RANK Ligand inhibitor indicated for the prevention of SREs in patients with bone metastases from solid tumors was approved by the U.S. Food and Drug Administration (FDA) on Nov. 18, 2010.  The approval was based in part on results described in this publication. XGEVA is not indicated for the prevention of SREs in patients with multiple myeloma.

Key Study ResultsFor the primary endpoint of this study, the median time to first on-study SRE (defined as fracture, radiation to bone, surgery to bone, or spinal cord compression) was 20.6 months for patients receiving XGEVA and 16.3 months for patients receiving Zometa (hazard ratio 0.84, 95 percent CI: 0.71-0.98), which is statistically significant for non-inferiority (p=0.0007). Although numerically greater, the delay in the time to first SRE associated wi
'/>"/>

SOURCE Amgen
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Paper in International Journal of Oncology Reports Alfacells ONCONASE(R) Suppresses Intracellular Oxidative Stress
2. Adlyfe Study on the Detection of Misfolded Proteins Published in the Journal Transfusion
3. Nebivolol Lowers Blood Pressure in Mild-to-Moderate Hypertensive Patients as Demonstrated in a Study Published in the Journal of Clinical Hypertension
4. Results from Study Evaluating PROCRIT(R) in Intensive Care Unit Patients Published in New England Journal of Medicine
5. Hypertension: Journal of the American Heart Association Rapid Access Reports: Hispanics Hypertension Better Controlled With Equal Access to Care
6. Vaccine Study in New England Journal of Medicine Wrong in Concluding Mercury Exposures are Harmless, States SafeMinds
7. Risks Associated With Face Transplants May Be Lower Than Previously Thought, ASPS Journal Review Suggests
8. Studies Showing Significant Survival Improvement with Taxotere(R)-based Regimens in the Induction Treatment of Patients with Locally Advanced Head and Neck Cancer are Published in the Same Issue of the New England Journal of Medicine
9. Nebivolol Lowers Blood Pressure in African Americans With Stage I-II Hypertension as Demonstrated in a Study Published in the Journal of Clinical Hypertension
10. UPDATE: Nebivolol Lowers Blood Pressure in African Americans With Stage I-II Hypertension as Demonstrated in a Study Published in the Journal of Clinical Hypertension
11. The New England Journal of Medicine Publishes First Clinical Results for MedImmunes Chitinase-like Protein YKL-40 in Patients With Asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... 22, 2013   Upsher-Smith Laboratories, Inc. ... its global Phase III clinical trial for ... for the management of epilepsy in adults, ... is specifically engineered to provide convenient once-daily ... levels observed with currently available treatment options.  ...
(Date:5/22/2013)...   Life Line Screening  (LLS), a leading ... creation of a unique partnership with MCM Solutions ... is a population health management organization. LLS will provide ... These important expanded services will help MCM and its ... reduces cost of care when individuals are able to ...
(Date:5/22/2013)... -- Ranbaxy Laboratories Limited (hereafter, Ranbaxy), a subsidiary ... announced on May 22 the actions that Ranbaxy ... conduct under prior management ( ... to support Ranbaxy in its efforts to address ... led to the investigations by the U.S. Department ...
Breaking Medicine Technology:Upsher-Smith Successfully Completes Phase III Study Of USL255 (Extended-Release Topiramate) For Adjunctive Treatment Of Epilepsy In Patients With Refractory Partial-Onset Seizures 2Upsher-Smith Successfully Completes Phase III Study Of USL255 (Extended-Release Topiramate) For Adjunctive Treatment Of Epilepsy In Patients With Refractory Partial-Onset Seizures 3Upsher-Smith Successfully Completes Phase III Study Of USL255 (Extended-Release Topiramate) For Adjunctive Treatment Of Epilepsy In Patients With Refractory Partial-Onset Seizures 4Life Line Screening and MCM Solutions for Better Health Announce New Partnership 2
... Aethlon Medical, Inc., (OTCBB: AEMD) disclosed today that its ... following letter to shareholders. (Photo:   ... Last December, I authored a shareholder letter which referenced ... for innovative new therapeutic strategies to evolve as escalating ...
... Name Medical Center (HNMC) in Teaneck, NJ, announced ... Management (PM) and revenue cycle management (RCM) software ... for distribution to hospital-affiliated physicians under the federal ... testing—including speed, functionality, and interfaces—to reach this benchmark. ...
Cached Medicine Technology:Aethlon Medical Releases Shareholder Letter 2Aethlon Medical Releases Shareholder Letter 3Aethlon Medical Releases Shareholder Letter 4Aprima Earns High Marks at Holy Name Medical Center 2Aprima Earns High Marks at Holy Name Medical Center 3
(Date:5/22/2013)... Angeles, California (PRWEB) May 22, 2013 According ... article entitled “Women Have More Options for Breast Cancer Surgery,” ... an opportunity to approach this disease in a whole ... has been developed, women now face breast cancer and ... (Go to goo.gl/ARqoN). , “Before the introduction of plastic surgery ...
(Date:5/22/2013)... ARBORA University of Michigan study challenges previous research ... Baseball. , The study, a collaboration between researchers ... Florida, looks deeper into the controversial argument over ... strikes for pitchers of the same race. It ... said Jason Winfree, associate professor of sport management ...
(Date:5/22/2013)... By Maureen Salamon HealthDay Reporter , , WEDNESDAY, ... each cause a great deal of suffering, but new ... linked to something else entirely -- a smaller brain. ... double the risk of depression, scientists wanted to determine ... The difference in size -- about 2 percent -- ...
(Date:5/22/2013)... York (PRWEB) May 22, 2013 Phelps ... established the Westchester Lung Nodule Center for individuals ... receive lung cancer care. Lung cancer is the deadliest form ... more people in the U.S. die from lung cancer than ... with all cancers, early detection increases survival rates. It ...
(Date:5/22/2013)... Lake City, Utah (PRWEB) May 22, 2013 ... R.D., published an article today on Tatalou.com sharing a recipe ... “ Make Your Own Healthy Energy Bars ,” takes a ... with a few important twists. , “Every day it gets ... are entering our bodies,” said Chevreau. “The size of the ...
Breaking Medicine News(10 mins):Health News:Breast Augmentation – New Option for Breast Cancer Surgeries 2Health News:U-M study challenges notion that umpires call more strikes for pitchers of same race 2Health News:Having Both Migraines, Depression May Mean Smaller Brain 2Health News:Having Both Migraines, Depression May Mean Smaller Brain 3Health News:Phelps Memorial Hospital Center Establishes The Westchester Lung Nodule Center To Diagnose And Administer Lung Cancer Care 2Health News:Phelps Memorial Hospital Center Establishes The Westchester Lung Nodule Center To Diagnose And Administer Lung Cancer Care 3Health News:How To "Make Your Own Healthy Energy Bars" 2
... lag behind recommended levels , THURSDAY, Oct. 1 (HealthDay News) ... vaccinate children against seasonal flu, as well as swine flu. ... for children 6 months to 18 years, according to the ... Practices. , A report in the agency,s Oct. 2 ...
... ... Management Program for Fourth Consecutive Year , ... Albany, N.Y. (Vocus) October 2, 2009 -- For the fourth consecutive year, ... upstate New York by Health Industries Research Companies (HIRC), a national, independent research ...
... Pa., Oct. 1 Today America,s Health Insurance ... Harrisburg and talked to Capital BlueCross and guests ... Attendees included Pennsylvania Insurance Department Commissioner Joel Ario, ... representatives from area hospitals and providers, and representatives ...
... State Nurses Association (WSNA), representing more than 16,000 registered nurses ... against MultiCare Health System for unilaterally implementing a mandatory vaccination ... flu vaccination or to wear face masks as a condition ... who do not comply with the policy. The lawsuit seeks ...
... PRINCETON, N.J., Oct. 1 The Health Research and Educational ... Hospital Association, has been awarded a grant of nearly $1 ... coverage to uninsured children. , Health and Human Services Secretary ... programs in 41 states and the District of Columbia to ...
... Oct. 1 Stater Bros. Charities and Inland Women ... the Cure , which will take place on Sunday, ... local community together to help fight cancer and over ... , "Last year,s turnout was amazing with 1,700 walkers, ...
Cached Medicine News:Health News:Children Need Seasonal Flu Vaccine, Experts Say 2Health News:CDPHP Honored for Best Disease Management Program in Upstate New York 2Health News:CDPHP Honored for Best Disease Management Program in Upstate New York 3Health News:Capital BlueCross Invites National Association Leader Karen Ignagni to Discuss Status of Health Care Reform 2Health News:Washington State Nurses Association Seeks Injunction in Federal Court to Block Mandatory Vaccination Policy by MultiCare Health System 2Health News:Hospital Group Receives $1 Million Grant to Help Patients Access Health Insurance 2Health News:4,000 Registered for Redlands' 2nd Annual Believe and Walk for the Cure 2Health News:4,000 Registered for Redlands' 2nd Annual Believe and Walk for the Cure 3
... evenly and safely, the Hoefer GD 2000 uses ... applied beneath the gel through a heavy aluminum ... up to 33 x 44 cm in as ... provides even heat distribution and even vacuum distribution ...
This double-up gel dryer system, 200-240 V, includes 2 Model 583 gel dryers, HydroTech™ vacuum pump, and double-up rack....
... a hot air drying device for polyacrylamide and ... cellophane support for easy viewing. The assembly table ... surface for the drying frame. The dryer holds ... 115 V, 60 Hz system includes a gel ...
The GelAir™ dryer is a component of the GelAir drying system. Supplied as a 115 V, 60 Hz gel drying oven....
Medicine Products: