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The Japanese Cancer Association and Debiopharm Group Present Doctors Oshima and Tanaka with the 2012 'JCA-Mauvernay Award' for their Innovative and Outstanding Cancer Research
Date:9/21/2012

is studies indicate that cooperation of Wnt activation and PGE2 associated inflammation is essential for gastric cancer development. He has shown the role of both inflammation and Wnt pathway separately in gastric cancer by using his mouse model. These findings will contribute significantly to understanding the biological in vivo mechanism of gastric cancer development.

Dr Shinji Tanaka is an associate professor in the Department of Hepato-Biliary-Pancreatic Surgery at the Tokyo Medical and Dental University.

His work focuses on using clinical tissue samples to analyse refractory digestive cancers including hepato-biliary, pancreatic, oesophageal, and scirrhous gastric carcinomas, which have a poor outcome even after curative surgical resection.

His lab has analysed over 1000 clinical samples from surgically resected tissue and isolated 28 novel cancer related genes. This has allowed them to clarify several oncogenic mechanisms.

Dr Tanaka isolated a novel angiogenic switch gene called angiopoietin-2. Angiogenic switch is a hallmark of cancer progression in-vivo. Recent clinical trials of the anti-angiopoietin-2 peptide revealed it as a promising agent to treat advanced cancers that are resistant to VEGF inhibitors.

His studies have demonstrated that oxidative stress in the host tissues is the only predictive factor of the recurrence after curative resection in hepatocellular carcinoma. And more recently he identified one type of agent specifically targeting cancer stem cell. This discovery should lead to a promising approach for radical cure of pancreatic cancer.

About Debiopharm Group™

Debiopharm Group™ (Debiopharm) is a Swiss-based global biopharmaceutical group of companies with a focus on the development of prescription drugs that target unmet medical needs. The group in-licenses, develops and/or co-develops promising biological and small molecule drug candidates having reached clinical d
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SOURCE The Debiopharm Group
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