Navigation Links
The Future of GPCRs in Drug Discovery: Novel Technologies, Leading Companies, and Opportunities for Target Expansion
Date:11/8/2010

modulators of GPCR function 62

Figure 4.13: Schematic of allosteric modulator approach 63

Figure 4.14: Comparison of biased ligands and conventional GPCR ligands 69

Figure 5.15: Approach to more selective antipsychotic drugs 76

Figure 5.16: Lorcaserin, enhanced 5-HT2C receptor selectivity 78

Figure 7.17: Continued opportunities to exploit GPCRs 109

Figure 7.18: Angiotensin AT1 antagonists - the patent cliff in the US 113

List of TablesTable 1.1: Classes of GPCRs 19

Table 1.2: Sales of GPCR-directed drugs achieving sales of >$250m in 2009 24

Table 3.3: Sales of AT1 receptor antagonists ($m), 2009 42

Table 5.4: GPR119 agonists in development for the treatment of type 2 diabetes 82

Table 5.5: DP2 antagonists in development for the treatment of asthma 83

Table 6.6: GPCR pipeline of 7TM Pharma 93

Table 6.7: GPCR pipeline of Actelion 94

Table 6.8: GPCR pipeline of Addex Pharmaceuticals 96

Table 6.9: GPCR pipeline of Arena Pharmaceuticals 97

Table 6.10: GPCR pipeline of Domain Therapeutics 101

Table 6.11: GPCR pipeline of Euroscreen 102

Table 6.12: GPCR pipeline of Tranzyme Pharma 105

Table 7.13: Drugs in advanced development, targeting unexploited GPCRs 115

Companies mentionedTo order this report:Drug Discovery and Development Industry: The Future of GPCRs in Drug Discovery: Novel technologies, leading companies, and opportunities for target expansion

More  Market Research Report

Check our  

SOURCE Reportlinker
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Covance Reports Third Quarter Financial Results and Takes Actions to Strengthen Future Performance
2. Saudi Arabias King Abdullah International Research Center Signs With Varian Medical Systems and IMRIS for Future Technology for Use in Radiotherapy
3. Media Statement From Amedisys on Dr. Steven H. Landers NEJM Commentary on the Future of Home Care
4. Reportlinker Adds Lung Cancer Drug Futures
5. Reportlinker Adds Prostate Cancer Drug Futures
6. Reportlinker Adds Renal Cell Carcimona Cancer Drug Futures
7. Sen. Harry Reid to Medco Employees: Technology and Innovation Integral to Sustainable Healthcare Reform and Nevadas Future
8. Interdisciplinary Convergent Approach May Represent Future for Treatment of Atrial Fibrillation
9. Lead Plaintiffs Attorney In Forest Pharmaceuticals Case Says $313 Million Award Is Tip of the Iceberg of Future Off-Label Marketing Lawsuits
10. Pharmaceutical Industry Insiders, VIPs All Coming Together for Future of Pharma Market, Pharmaceutical Competitive Intelligence
11. Reportlinker Adds Epigenetics: Current and future applications that are driving novel drug discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... , Jan. 15, 2014 AARP Foundation today announced it ... adults suffering from the severe cold weather that has gripped ... to helping those in need; so to support these emergency ... up to $250,000, which could mean up to $500,000 in ...
(Date:1/15/2014)... , Jan. 15, 2014  Humberto C. Antunes,  Galderma  worldwide ... from the Journal of Drugs in Dermatology ... Conference (ODAC). The event is January 17-20, 2014, at the Omni ... . The ODAC is a distinguished ...
(Date:1/15/2014)... R.I. , Jan. 15, 2014 MultiCell Technologies, ... filed a U.S. provisional patent application concerning composition of ... to achieve targeted tumor cell death.  ... small noncoding double stranded RNA molecules (VSRNAs) which interfere ...
Breaking Medicine Technology:AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3
(Date:7/9/2014)... 10, 2014 -- The World Health Organization recommends that ... moderate to vigorous physical activity (MVPA) each day. ... MVPA during school hours. Therefore, it stands to ... increase MVPA. In a new study scheduled for ... confirmed that time spent outdoors after school was positively ...
(Date:7/9/2014)... After Susan Wakulich was told she had an aneurysm, she ... of her. , "I was devastated," said Wakulich, who is ... knew this was a serious diagnosis. Then I met Dr. ... involved a less invasive procedure. It was something I didn,t ... in a multi-center U.S. clinical trial to evaluate the safety ...
(Date:7/9/2014)... findings from Fox Chase Cancer Center paint a relatively ... of breast cancers that have spread to the chest ... that grow into the skin, regardless of size and ... as stage III and called "locally advanced" tumors, ... cancer, often with poor survival. Locally advanced breast cancers ...
(Date:7/9/2014)... By looking at ... structure and function, personality, life experiences and genetics, researchers can ... binge drinking within the next two years. Impulsivity, hopelessness, sensation-seeking ... events and a family history of drug use contribute to ... child had had a single drink at age 14 was ...
(Date:7/9/2014)... reputation for being highly toxic, but when used in the ... to offer potential health benefits in a range of issues, ... compound (AP39), designed and made at the University of Exeter, ... of very small amounts of the substance to the right ... have already found that the compound protects mitochondria the ...
Breaking Medicine News(10 mins):Health News:Go play outside! Outdoor time promotes physical activity in youth 2Health News:New type of stent could help some brain aneurysm patients 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 3Health News:What drives a child to abuse alcohol? 2Health News:Rotten egg gas holds key to healthcare therapies 2
... 20, 2011) When two adjacent discs in the low ... or other symptoms, replacement with artificial discs can be a ... data from a randomized, multicenter trial recently published in the ... studies have compared single-disc replacement with fusion but this is ...
... All children should be screened for high cholesterol when they,re ... the National Lipid Association. The group also urges that ... elevated cholesterol be screened for cholesterol with a simple blood ... people know if a history of high cholesterol runs in ...
... (HealthDay News) -- People who have psoriasis and hypertension are ... more medications to control it, a new study suggests. ... causes itchy, thickened, dry, red patches on the skin. ... 835 patients who had psoriasis and hypertension. Their cases were ...
... as follows: SESSION I / Monday, May 23 ... Rates of Acute Coronary Syndrome Patients in Real World Clinical ... Gandhi SK2, Bhandary D2, Stephenson JJ1, Gold A2, Fu AC1, ... Wilmington, Del. SESSION II / Tuesday, May 24 ...
... Aage Moller of UT Dallas is known throughout the world ... But back at The University of Texas at Dallas, he,s ... Moller received the President,s Teaching Excellence Award for Tenure-Track ... was selected from among more than 100 eligible faculty members ...
... provides evidence for significant differences between new and old ... a cheap, rapid and effective way to monitor the ... preservatives, blood stored in banks continues to age, resulting ... subsequent changes to cell properties and function. There ...
Cached Medicine News:Health News:2-year results: Artificial disc a viable alternative to fusion for 2-level disc disease 2Health News:Experts Say Cholesterol Screenings Should Start in Childhood 2Health News:Psoriasis, High Blood Pressure May Be Linked 2Health News:HealthCore presents ISPOR poster sessions 2Health News:UT Dallas' Moller receives teaching award 2Health News:Research provides insight into quality of stored blood used for transfusions 2Health News:Research provides insight into quality of stored blood used for transfusions 3
... provides anterior column support for single or ... to L5. The system consists of one ... that are stacked to a desired height, ... Fiber Reinforced Polymer material emulates the biomechanical ...
... Jaguar Lumbar I/F Cage system is a ... separate the mechanical and biologic functions of ... Lumbar I/F Cage provides a device designed ... and uses autologous cancellous bone, the best ...
... transmitted through sorted fiberglass bundles ... transmit it to a user's ... designed for rough, industrial handling ... low cost if they should ...
The original Zeppelin High-Speed Motordrill System has been developed to rapidly cut bone, plastic and metal with utmost precision. 120-150 psi - 90.000 rpm - 90g - autoclavable at <134 C....
Medicine Products: