Navigation Links
The Future of GPCRs in Drug Discovery: Novel Technologies, Leading Companies, and Opportunities for Target Expansion
Date:11/8/2010

aches such as allosteric modulation, bifunctional ligand design, and the targeting of dimeric receptors. Both old and new targets are considered in terms of their potential to offer fresh opportunities, and particular attention is given to the current and future roles of orphan receptors. Finally, the report profiles a range of companies specializing in aspects of GPCR drug discovery, and the market outlook is summarized.

List of TablesThe Future of GPCRs in Drug Discovery

Executive summary 10

Introduction 10

Characteristics of GPCRs 10

Commercial exploitation 11

New approaches 12

New opportunities 13

Specialist company profiles 14

Market outlook for dugs targeting GPCRs 14

Chapter 1 Introduction 18

Summary 18

Introduction 18

GPCRs in the human genome 19

Additional opportunities 20

The leading class of drug targets 21

Commercially validated targets 23

Chapter 2 Characteristics of GPCRs 28

Summary 28

Introduction 28

Protein structure 29

Functional receptors 31

Second messengers 31

Agonists, antagonists, partial agonists, and inverse agonists 33

Chapter 3 Commercial exploitation 36

Summary 36

Introduction 37

Current successes 37

Targeted GPCRs 44

Unexplored targets 47

Difficult targets 50

Opportunities 50

Chapter 4 New approaches 54

Summary 54

Introduction 55

Screening methods 56

Structure-based methods 57

Knowledge-based methods 60

Allosteric modulators 62

Bifunctional ligands 65

Dimeric receptor targeting ligands 66

Biased ligands 68

Chapter 5 New opportunities 72

Summary 72

Introduction 73

Enhanced selectivity 73

Atypical antipsychotics 75

Lorcaserin 78

Adenosine A2A antagonists 79

New targets 80

Ghrelin antagonists 81
'/>"/>

SOURCE Reportlinker
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Covance Reports Third Quarter Financial Results and Takes Actions to Strengthen Future Performance
2. Saudi Arabias King Abdullah International Research Center Signs With Varian Medical Systems and IMRIS for Future Technology for Use in Radiotherapy
3. Media Statement From Amedisys on Dr. Steven H. Landers NEJM Commentary on the Future of Home Care
4. Reportlinker Adds Lung Cancer Drug Futures
5. Reportlinker Adds Prostate Cancer Drug Futures
6. Reportlinker Adds Renal Cell Carcimona Cancer Drug Futures
7. Sen. Harry Reid to Medco Employees: Technology and Innovation Integral to Sustainable Healthcare Reform and Nevadas Future
8. Interdisciplinary Convergent Approach May Represent Future for Treatment of Atrial Fibrillation
9. Lead Plaintiffs Attorney In Forest Pharmaceuticals Case Says $313 Million Award Is Tip of the Iceberg of Future Off-Label Marketing Lawsuits
10. Pharmaceutical Industry Insiders, VIPs All Coming Together for Future of Pharma Market, Pharmaceutical Competitive Intelligence
11. Reportlinker Adds Epigenetics: Current and future applications that are driving novel drug discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... , Dec. 24, 2014 Soligenix, Inc. ... biopharmaceutical company developing products that address unmet medical ... biodefense, announced today that on December 24, 2014 ... The Company raised approximately $2.3 million ... to use the net proceeds from the offering ...
(Date:12/24/2014)... and FARMINGTON, Conn. , ... (NYSE MKT: PTN), a biopharmaceutical company developing targeted, ... with significant unmet medical need and commercial potential, ... private placement of 2,050,000 shares of its common ... shares of its common stock.  Funds under the ...
(Date:12/24/2014)...  Advanced Medical Isotope Corporation ("AMIC") (OTCQB: ADMD), a ... development of brachytherapy devices and medical isotopes for ... has filed a de novo submission ... marketing clearance for its patented Y-90 RadioGel(TM) device ... Drug and Cosmetic Act (the "Act").  ...
Breaking Medicine Technology:Soligenix Announces Closing of Public Offering of Units 2Soligenix Announces Closing of Public Offering of Units 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 2Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 3
(Date:12/25/2014)... Thompson HealthDay Reporter WEDNESDAY, ... in on a "fountain of youth" drug that can delay ... adults, a new study suggests. Seniors received a significant ... targets a genetic signaling pathway linked to aging and immune ... The experimental medication, a version of the drug rapamycin, ...
(Date:12/25/2014)... 25, 2014 Thousands of transvaginal mesh ... in a number of multidistrict litigations currently underway in ... Liebhard LLP reports. According to an Order issued on ... a Joint Status Conference in all of the proceedings ... been directed to submit a proposed agenda to the ...
(Date:12/25/2014)... California (PRWEB) December 25, 2014 Plugin ... of ProFire 5k. A fully customizable business presentation tool ... , “Adding the ProFire 5k business tool, users can ... Christina Austin, CEO of Pixel Film Studios. “ProFire 5k ... and style to add professionalism to a presentation” , ...
(Date:12/25/2014)... Each year trauma accounts for approximately ... admissions across the nation (according to the Centers ... National Hospital Ambulatory Medical Care Survey collected data ... 2010. They estimated that there were between 3.5 and ... primary diagnosis of broken bone or fracture. , ...
(Date:12/24/2014)... (PRWEB) December 25, 2014 AlignLife of ... unable to afford certain items. During the holiday season, AlignLife ... collected over 70 toys," says Dr. Sara Mahalko-Leonhardt, owner of ... staff such joy, knowing that we are able to give ... had it not been for the generosity of our patients." ...
Breaking Medicine News(10 mins):Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2
... monitoring helped push cure rates to nearly 88 percent ... Research Hospital acute lymphoblastic leukemia (ALL) treatment protocol and ... battling the most common childhood cancer. A report ... of Clinical Oncology noted that overall survival jumped 30 ...
... News) -- Most head and neck cancer patients can ... treatment, but several factors may be associated with poor ... patients who were assessed nearly three years after they ... neck cancer. The U.S. researchers gave a speaking ...
... to develop genital cancer, especially as they grow older. ... sexes suffer from the condition, which is extremely difficult to ... of the similarity of the disease to human genital cancer ... Several human genital cancers, including cervical tumours, are known ...
... Nasal congestion can be a sign of severe asthma, ... when it comes to nasal complaints. Furthermore, more severe ... reveals a study from the Sahlgrenska Academy,s Krefting Research ... Respiratory Research , the population study included 30,000 randomly ...
... the effects of monensin emerged in a project investigating ... the growth of prostate cancer cells. The project involved ... found that small amounts of compounds disulfiram (Antabus), ... growth of prostate cancer cells without significant effects on ...
... The hectic pace of the holiday season can make it ... conditions to maintain normal routines and medication schedules. This can ... errors, according to the American Pain Foundation. But a ... over the holidays, the foundation says. If you,re traveling, ...
Cached Medicine News:Health News:Intensive chemotherapy can dramatically boost survival of older teenage leukemia patients 2Health News:Intensive chemotherapy can dramatically boost survival of older teenage leukemia patients 3Health News:Speech, Swallowing Usually OK After Head & Neck Cancer Therapy 2Health News:A possible cause -- and cure -- for genital cancer in horses? 2Health News:Nasal congestion can mean severe asthma 2Health News:Finnish researchers find a compound that prevents the growth of prostate cancer cells 2Health News:Hectic Holiday Pace Can Upset Medication Schedule 2
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
Medicine Products: