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The Epilepsy Research Foundation and Milken Family Foundation Announce Prestigious Translational Research Grants for Two Pioneering Epilepsy Therapies
Date:12/7/2009

lion people in the United States and 50 million people worldwide," said Eric R. Hargis, President and CEO of the Epilepsy Foundation. "Even with current treatments, approximately 30 percent of people with epilepsy live with uncontrolled seizures. Our goal in awarding these grants is to help provide them with new and better treatment options."

"We are gravely in need of novel epilepsy treatments with new underlying modes of action for all patients living with seizure conditions, and in particular to provide more effective options for young children and for women of childbearing age," said Howard R. Soule, Ph.D., Chief Science Officer for the Milken Family Foundation. "We are proud to support high-caliber research in the field of epilepsy, and truly hope to see progress in making available effective and tolerable treatments in our lifetimes."

The December 2009 Grant Recipients

Benefits of the Ketogenic Diet Lead to Discovery of New Anticonvulsant

Nathan Fountain, M.D., Director, F.E. Dreifuss Comprehensive Epilepsy Program, University of Virginia and Thomas Sutula, M.D., Ph.D., Detling Professor and Chair, University of Wisconsin-Madison and Co-founder, Chief Technical Officer of NeuroGenomeX, Inc., will be assessing the clinical activity of 2-deoxy-D-glucose (2DG) in reducing seizure frequency in subjects with a history of frequent seizures. The investigators will use the grant funding in an initial Phase II safety, tolerability and proof-of-principle clinical study of 2DG. By investigating the mechanisms of anticonvulsant action of the ketogenic diet (isocaloric replacement of carbohydrates by fats and proteins), researchers identified the inhibition of glycolysis as a novel mechanism of anticonvulsant and antiepileptic action. Administration of 2DG, a known inhibitor of glycolysis, also demonstrated acute anticonvulsant action in early evaluation, and had pronounced anticonvulsant and antiepi
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SOURCE Epilepsy Therapy Project
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