Navigation Links
The Children's Hospital of Philadelphia: New Gene-Searching Method Uncovers Possible New Targets for Crohn's Disease Drugs
Date:2/26/2009

analytic equipment to sweep through the full range of all 23 human chromosomes and detect the most significant gene variants associated with a given disease. Those variants, each a change in a single DNA base, are called single nucleotide polymorphisms (SNPs).

However, individual GWA studies often do not have the statistical power to detect subtle but important variants that are involved in disease development. By using an algorithm developed by Kai Wang, Ph.D., at the Center for Applied Genomics, Hakonarson's study team created a pathway-based approach that seeks out interacting or related genes along the same biological pathway. "We applied our pathway-based approach to GWA data for Crohn's disease, but conducted the search without starting with a hypothesis focused on a specific suspected pathway," said Hakonarson. "Among hundreds of known biological pathways, the one that surfaced from the analysis as being most significant included genes already known to be relevant to the biology of Crohn's disease."

That pathway, the interleukin 12 (IL12) pathway, governs cell receptors involved in the development of Crohn's disease. Hakonarson added that the IL12 pathway might be more correctly referred to as the IL12/IL23 pathway, since IL12 receptor signaling converges with signaling on another receptor, IL23. Previous work by other researchers had shown that monoclonal antibodies that block the IL12 or IL23 receptor show some clinical success in treating Crohn's disease.

"As we better understand the gene pathways operating in Crohn's disease, we are uncovering more potential targets for effective drug treatments," said pediatric gastroenterologist Robert Baldassano, M.D., a study co-author and the director of the Center for Pediatric Inflammatory Bowel Disease at Children's Hospital. He added that developing targeted therapies based on gene pathways might allow doctors to tailor treatments to a patient's genetic profile.
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Childrens Hospital Receives $6.7 Million Grant From Gates Foundation to Study Influenza Vaccine in Pregnant Women in Asia
2. IlluminOss Medical Announces First Human Case Utilizing a Unique, New, Minimally Invasive Technology for Fracture Repair is Performed at Medical Hospital del Trabajadar in Santiago, Chile
3. Data from Phase 2 Study of Peramivir in Patients Hospitalized with Influenza Presented at the XI International Symposium on Respiratory Viral Infections
4. 10-State Project to Study Methods to Reduce Central Line-Associated Bloodstream Infections in Hospital ICUs
5. CVS Caremark Study Finds Non-Adherent Heart Failure Patients Almost Twice as Likely to be Re-Hospitalized Within a Year
6. British Midlands University Announces Use of Gene Technology to Fight Lethal Hospital Acquired Infection
7. Huntington Hospital Surgeon Performs First Single Port Resection on Colorectal Cancer Patient in CA
8. Studies Examine Quality of Care for Hospitalized Sickle Cell Disease Patients and Effective Methods for Detecting Risk of Stroke in Children With This Disorder
9. Kleinert Kutz Hand Surgeons Perform Fifth U.S. Hand Transplant in Record Time at Jewish Hospital Hand Care Center
10. Dominos Pizza Pledges Support to the Fifth Annual St. Jude Childrens Research Hospital(R) Thanks and Giving(R) Campaign
11. Miami Jewish Home and Hospital, Berma Research Group and Segal Institute for Clinical Research Enrolling Local Patients in Study of Investigational Therapy to Treat Alzheimers Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... , Sept. 23, 2014 CASI Pharmaceuticals, ... dedicated to the acquisition, development and commercialization of innovative ... the global market with a primary focus on ... Rajesh C. Shrotriya , MD, Chairman and Chief Executive ... Directors.  The appointment was made in connection with the ...
(Date:9/23/2014)...  As physicians seek information about drugs today, ... learn about new therapies or ask questions of ... report by global sales and marketing consultants at ... a customized mix of digital media and visits ... engage with physicians. And, productive engagement with physicians ...
(Date:9/23/2014)... 23, 2014 Avillion LLP, ... appointment of Jarrod Longcor as Chief ... responsible for structuring, negotiating and executing successful strategic ... as providing management and strategic leadership to the ... leadership team. Mr Longcor brings to ...
Breaking Medicine Technology:CASI Pharmaceuticals Announces Appointment Of Rajesh C. Shrotriya, MD To The Board Of Directors 2CASI Pharmaceuticals Announces Appointment Of Rajesh C. Shrotriya, MD To The Board Of Directors 3CASI Pharmaceuticals Announces Appointment Of Rajesh C. Shrotriya, MD To The Board Of Directors 4As sales reps see doors close for in-person visits with physicians, digital doors open communication 2As sales reps see doors close for in-person visits with physicians, digital doors open communication 3As sales reps see doors close for in-person visits with physicians, digital doors open communication 4As sales reps see doors close for in-person visits with physicians, digital doors open communication 5Avillion Appoints Jarrod Longcor as Chief Business Officer 2
... Mont., May 8, 2012  Bacterin International Holdings, Inc. ... in the development of revolutionary bone graft material ... third national GPO contract, a three-year agreement with ... and contracting company.  The agreement provides Bacterin,s full ...
... Heska Corporation (NASDAQ: HSKA ), a provider ... announced that its Board of Directors has declared a cash ... payment will be distributed on July 10, 2012 to stockholders ... to pay a regular quarterly dividend of $0.10 per share ...
Cached Medicine Technology:Bacterin International Signs Its Third National GPO Contract with Novation 2Bacterin International Signs Its Third National GPO Contract with Novation 3Bacterin International Signs Its Third National GPO Contract with Novation 4Heska Announces Quarterly Dividend of $0.10 Per Share 2
(Date:9/23/2014)... 2014 Airbus Helicopters Inc. (AHI) is ... as the 2014 Vision Zero Aviation Safety Award ... database, a free flight safety service the company provides ... - Air Medical Specialist for Airbus Helicopters Inc., presented ... check during the Air Medical Transport Conference Annual Community ...
(Date:9/23/2014)... has been shown to be a driving force ... often develops due to chronic inflammation caused by ... has relatively few effective treatment options. Now, scientists ... demonstrated for the first time in preclinical studies ... as astrocyte elevated gene-1 (AEG-1) halts the development ...
(Date:9/23/2014)... York, NY (PRWEB) September 23, 2014 ... that it has entered into a contract to provide ... system to Elderplan, Inc., one of New York City’s ... MJHS, will deploy the eCaring system to help enhance ... , “For nearly 30 years, Elderplan has been ...
(Date:9/23/2014)... EORTC investigators will present the results of their ... 2014 in Madrid. , Joint Symposium: ESMO-ASCO: ... Monday, September 29, 11:00 AM - 12:30 PM, ... Molecular Screening Platforms support new forms of cancer ... program. , Proffered Paper session: Melanoma and ...
(Date:9/23/2014)... Health has awarded $10.1 million in supplemental funding to ... effects of sex in preclinical and clinical studies. , ... and is a catalyst for considering sex as a ... subjects in preclinical research can obscure key findings related ... progressive approach will result in greater awareness of the ...
Breaking Medicine News(10 mins):Health News:Protean wins Airbus Helicopters Vision Zero Aviation Safety Award 2Health News:Protean wins Airbus Helicopters Vision Zero Aviation Safety Award 3Health News:Protean wins Airbus Helicopters Vision Zero Aviation Safety Award 4Health News:Study uncovers genetic driver of inflammation, uses it to prevent and treat liver cancer 2Health News:eCaring Signs Care Management Contract with Elderplan, Inc. 2Health News:EORTC presentations at ESMO 2014 Congress 2Health News:EORTC presentations at ESMO 2014 Congress 3Health News:New supplemental awards apply sex and gender lens to NIH-funded research 2Health News:New supplemental awards apply sex and gender lens to NIH-funded research 3
... researchers intrigued, egging them on to unlock the secrets embedded ... comprehend the link between profound experiences and their association with ... of the brain of Christian Nuns, while they recalled divine ... MRI of 15 Canadian nuns to get an insight into ...
... only reverses the arterial dysfunction caused by fatty foods but ... the meal, according to new research from Indiana University. ... are part of a growing focus on the effect food ... as the postprandial state. After a fatty meal, arteries lose ...
... conducted towards pest control have lead to the discovery ... of California, have stated that the newly discovered enzyme ... were initially looking for biological pest controls, might actually ... and other inflammatory diseases. It has been reported that ...
... Americans from the year 2000 have been getting poorer. ... in the October issue of the American Journal of Preventive ... climbing rapidly. The researchers have also reported that this growth ... in severe poverty and that ‘moderate’ poverty has grown in ...
... transfusions of blood products from recovering patients may help reduce ... of a pandemic in// future. ,The researchers say ... who received blood transfusions from people who had recovered had ... from the flu. ,The study, which is a ...
... of the University of Sao Paulo Medical School in Brazil ... getting the best care in case of chronic coronary artery ... to be published in the September edition of the Journal ... to receive their physician-recommended treatment showed a significantly lower incidence ...
Cached Medicine News:Health News:Researchers seek to demystify brain activity during mystical encounters 2Health News:A Serving of Exercise After That Saturated Fat 2Health News:Pest Control research Leads to Pain Control Discovery 2Health News:Pest Control research Leads to Pain Control Discovery 3Health News:Increasing Levels Of Severe Poverty In US Could Jeopardize Public Health 2Health News:Patient’s Individual Cardiologist Best Judge For Deciding Appropriate Treatment In Chronic Coronary Artery Diseas 2Health News:Patient’s Individual Cardiologist Best Judge For Deciding Appropriate Treatment In Chronic Coronary Artery Diseas 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: