Navigation Links
The Blanchette Rockefeller Neurosciences Institute Identifies Groundbreaking New Therapies for Prevention and Treatment of Alzheimer's Disease
Date:1/11/2011

strains.  BRNI used a difficult training regimen for the mice in order to reveal that significant cognitive deficits occurred five months before plaques were detected in their brains, providing evidence that plaques and tangles are not at the root of the disease.

Treatments of Bryostatin and similar compounds synthesized at BRNI that target the enzyme PKCepsilon, which controls the creation of synapses at the molecular level, were administered for twelve weeks during the study.  While the compounds promoted the growth of new synapses and preservation of existing synapses, they also stopped the decrease of PKCepsilon and the increase of soluble beta amyloid, meaning that the treatments could be used to prevent the familiar hallmarks of Alzheimer's Disease, the plaques and tangles.  BRNI has received approval to move forward with Phase II clinical testing for Bryostatin to treat Alzheimer's Disease, which is set to begin within the next several months.  

The synaptogenic BRNI drugs have also shown potential for the treatment of traumatic brain injury (TBI), as recently reported in the journal Neurobiology of Disease, and stroke described in the Proceedings of the National Academy of Science in 2008 and 2009.

The target of the synaptogenic compounds is the same molecule identified as a biomarker for early diagnosis of Alzheimer's Disease in clinical trials conducted by BRNI and published in Neurobiology of Aging in 2010.  As a result of that study, researchers at the Institute are now working to develop a skin test for identifying Alzheimer's Disease in its early stages before significant progression.  

This study is part of BRNI's ongoing commitment to bridging the gap between fundamen
'/>"/>

SOURCE Blanchette Rockefeller Neurosciences Institute
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Blanchette Rockefeller Neurosciences Institute and Inverness Medical Innovations to Develop Commercial Test to Detect Early Alzheimers Disease
2. Nautilus Neurosciences and Tribute Pharmaceuticals Announce Exclusive Canadian License for CAMBIA™ (diclofenac potassium for oral solution) for the Acute Treatment of Migraine
3. Nautilus Neurosciences and Mission Pharmacal Announce Exclusive Co-Promotion Agreement for CAMBIA™ (diclofenac potassium for oral solution) for the Acute Treatment of Migraine to the Womens Health Market
4. US WorldMeds Acquires Solstice Neurosciences
5. Intellect Neurosciences, Inc. Announces Independent Studies on Copper Binding Properties of its Lead Candidate OXIGON(TM)
6. Neurosciences Institute Discovers Drug Extends Stroke Treatment Time to 24 Hours, Repairs Brain Tissue
7. Intellect Neurosciences, Inc. and Medical Research Council Technology (U.K.) Reach Important Milestone in Generating an Alzheimers Therapeutic Antibody
8. Knopp Neurosciences Receives Orphan Designation for KNS-760704 for Treatment of ALS
9. Knopp Neurosciences Initiates Phase 1 Clinical Trial of KNS-760704 in ALS Development Program
10. Intellect Neurosciences, Inc. and CHDI, Inc. Enter Into Compound Testing Agreement to Evaluate OXIGON(TM) as a Potential Treatment for Huntington Disease
11. Intellect Neurosciences, Inc. to Present Data on Alzheimers Vaccine at 13th International Congress of Immunology Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/4/2015)... 2015  Bayer HealthCare today announced that the ... the company,s Biologics License Application (BLA) for BAY ... seeking FDA approval of the investigational compound, proposed ... A in children and adults. ... to hemophilia A patients who need them," said ...
(Date:3/4/2015)...   HeartWare International, Inc . (NASDAQ: ... circulatory support technologies that are revolutionizing the treatment of ... Godshall is scheduled to present at the 2015 ... on Tuesday, March 10, 2015.  The conference is being ... in Florida . A ...
(Date:3/4/2015)... INDIANAPOLIS , March 4, 2015  Students from ... look at how new medicines are discovered. Through a ... and fourth-year medical students from IU School of Medicine ... physicians working at Lilly play different and important roles ... "As a former medical educator, scientific investigator, and ...
Breaking Medicine Technology:FDA Accepts Bayer's Biologics License Application for Investigational Treatment Option in Hemophilia A 2FDA Accepts Bayer's Biologics License Application for Investigational Treatment Option in Hemophilia A 3HeartWare Presentation At The 2015 Barclays Global Healthcare Conference To Be Webcast 2Lilly and IU School of Medicine Partner on Rotation Program for Medical Students 2Lilly and IU School of Medicine Partner on Rotation Program for Medical Students 3
(Date:3/5/2015)... (PRWEB) March 05, 2015 Building on ... with timely, relevant information, The Academy of Oncology Nurse ... titled, CONQUER: the patient voice ™ (CONQUER ™). ... affects millions of people and their loved ones each ... of AONN+. “More than ever, there is a need ...
(Date:3/4/2015)... (PRWEB) March 04, 2015 MyCpapStore.com, an ... to announce that they sell quality products designed to ... Nevada, this company obtains its merchandise from name-brand manufacturers, ... history of good performance. , Sleep apnea is a ... typically caused by reduced or restricted airflow. The CPAP ...
(Date:3/4/2015)... Las Vegas, NV (PRWEB) March 04, 2015 ... good as the fight that is the main event. For ... announced and that fight will be for the UFC Featherweight ... against the brash, often out-spoken native of Ireland, Conor “Notorious” ... the MGM Grand Garden Arena in Las Vegas, NV. , ...
(Date:3/4/2015)... March 04, 2015 Dr. Christopher Asandra, ... Medical Center today lamented the FDA’s recent decision ... (TRT). He argued that FDA’s conclusions are not ... men who suffer from testosterone deficiency. , “The FDA ... on testosterone replacement therapy,” said Dr. Asandra. “There is ...
(Date:3/4/2015)... Cook For Your Life (CFYL), a New ... to people touched by cancer, is launching its first ... by founder Ann Ogden, will be facilitated by Drexel ... partnership will expand the program from its base. , ... After going through her own cancer treatments, Ogden realized ...
Breaking Medicine News(10 mins):Health News:The Academy of Oncology Nurse & Patient Navigators Launches CONQUER: the patient voice™ to Help Meet the Informational Needs of Patients with Cancer 2Health News:Sleep Apnea Machines CPAP and BiPap Machines Now Available for Sale 2Health News:Cheap UFC 189 Tickets: Jose Aldo vs. Conor McGregor UFC 189 Ticket Prices Slashed by Ticket Down for Featherweight Title 2Health News:Cheap UFC 189 Tickets: Jose Aldo vs. Conor McGregor UFC 189 Ticket Prices Slashed by Ticket Down for Featherweight Title 3Health News:NuMale’s Dr. Christopher Asandra: FDA Suffering from “Premature Equivocation” on Issue of Testosterone and Risks 2Health News:Drexel University and Cook for Your Life Team Up 2Health News:Drexel University and Cook for Your Life Team Up 3Health News:Drexel University and Cook for Your Life Team Up 4Health News:Drexel University and Cook for Your Life Team Up 5
... new study, as the demand for facial cosmetic surgery has ... has never been more popular. Most products go down in ... have looked at how cosmetic surgery, as a product//, has ... ,They surveyed 1,600 members of the American Academy of Facial ...
... researchers , there is a new study on seedless ... 30 people across six Western states last summer and ... of Salmonella serotype senftenberg// most often found in meats ... ,Dr.Alicia, at the International Conference on Emerging Infectious ...
... a new study, screening of patients suffering from depression in ... on a regular basis.When you visit the doctor, he or ... as measuring blood pressure.// According to some experts it is ... could be worthwhile.Researchers at the Hopkins University in USh have ...
... researchers are investigating a new technique for mapping the back ... Age-related macular degeneration (AMD) is the leading cause of blindness ... now report on a technical advance that could be developed ... could then be fast-tracked for treatment before the condition takes ...
... The functioning of stem cells has an outstanding nature. Initially, ... cells, promising repair of damaged lung tissue. The potential of ... more specialised cells - is now well established.// Researchers at ... first creation of lung cells from stem cells in mice. ...
... at the Country University of Chicago, have been ... broad-spectrum antibiotic, Azithromycin, which is commonly prescribed for ... ,They arbitrarily allocated 150 adults with acute ... All patients got cough syrup (liquid dextromorphan) and ...
Cached Medicine News:Health News:Grapes, Melons Implicated in Outbreaks 2
Round knurled handle. Overall length 130 mm....
Optimum C/D/S Solution is a sterile cleaning, disinfecting, and storage solution for use with fluorosilicone acrylate and silicone acrylate rigid gas permeable (RGP) and hard contact lenses....
5 inch (12.7 cm), 2 x 5 mm blade....
Nicati foreign body spud....
Medicine Products: