Navigation Links
The Blanchette Rockefeller Neurosciences Institute Identifies Groundbreaking New Therapies for Prevention and Treatment of Alzheimer's Disease
Date:1/11/2011

MORGANTOWN, W.Va., Jan. 11, 2011 /PRNewswire-USNewswire/ -- A Blanchette Rockefeller Neurosciences Institute (BRNI) study published today in the Journal of Neuroscience reveals underlying causes for the degeneration of synapses in Alzheimer's Disease and identifies promising pharmaceutical solutions for the devastating condition that affects more than 5 million people in the United States. The BRNI study is the first to achieve fundamental molecular understanding of how synapses are lost in Alzheimer's Disease before the plaques and tangles develop. At the same time, it is the first study to demonstrate the comprehensive benefits of synaptogenic compounds in treating Alzheimer's Disease.

The BRNI study marks an important shift in our understanding of how Alzheimer's Disease is caused and should be treated.  Previous autopsy-based studies have shown the critical role of synaptic loss in producing dementia (though, not the reason behind the degeneration), yet for decades scientists and pharmaceutical companies have focused on ways to target the amyloid plaques and neurofibrillary tangles thought to play a role in causing Alzheimer's Disease.  By preventing the loss of synapses, BRNI's new therapeutics prevent the progressive symptoms of Alzheimer's Disease.

"Alzheimer's Disease is not primarily a disease of plaques and tangles as many had previously concluded, it is most importantly a disease of synapses," said Dr. Daniel Alkon, the scientific director of BRNI and co-author of the study, "This study found that treatments that target the loss of synapses in the Alzheimer's brain, can virtually eliminate all other elements of the disease – elevation of the toxic protein, A Beta, the loss of neurons, the appearance of plaques, and loss of cognitive function; the animals' brains were normalized."  

The study utilized mice genetically engineered to express the symptoms and pathology of human Alzheimer's Disease in two different strains.  BRNI used a difficult training regimen for the mice in order to reveal that significant cognitive deficits occurred five months before plaques were detected in their brains, providing evidence that plaques and tangles are not at the root of the disease.

Treatments of Bryostatin and similar compounds synthesized at BRNI that target the enzyme PKCepsilon, which controls the creation of synapses at the molecular level, were administered for twelve weeks during the study.  While the compounds promoted the growth of new synapses and preservation of existing synapses, they also stopped the decrease of PKCepsilon and the increase of soluble beta amyloid, meaning that the treatments could be used to prevent the familiar hallmarks of Alzheimer's Disease, the plaques and tangles.  BRNI has received approval to move forward with Phase II clinical testing for Bryostatin to treat Alzheimer's Disease, which is set to begin within the next several months.  

The synaptogenic BRNI drugs have also shown potential for the treatment of traumatic brain injury (TBI), as recently reported in the journal Neurobiology of Disease, and stroke described in the Proceedings of the National Academy of Science in 2008 and 2009.

The target of the synaptogenic compounds is the same molecule identified as a biomarker for early diagnosis of Alzheimer's Disease in clinical trials conducted by BRNI and published in Neurobiology of Aging in 2010.  As a result of that study, researchers at the Institute are now working to develop a skin test for identifying Alzheimer's Disease in its early stages before significant progression.  

This study is part of BRNI's ongoing commitment to bridging the gap between fundamental research in memory processes and the development of products and treatments for patients with Alzheimer's Disease and other memory impairments.

For more information on the Blanchette Rockefeller Neurosciences Institute please visit www.brni.org.  

About Blanchette Rockefeller Neurosciences Institute:

Created in 1999, BRNI is the world's only non-profit institute dedicated to the study of both human memory and diseases of memory.  Its primary mission is to accelerate neurological discoveries from the lab, including diagnostic tools and treatments, to the clinic where it can benefit patients who suffer from neurological and psychiatric diseases.

BRNI is operated in alliance with West Virginia University in Morgantown as well as in collaboration with other academic institutions such as Johns Hopkins University.  West Virginia Senator Jay Rockefeller founded the Institute in memory of his mother, Blanchette Hooker Rockefeller, who died of Alzheimer's disease.


'/>"/>
SOURCE Blanchette Rockefeller Neurosciences Institute
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Blanchette Rockefeller Neurosciences Institute and Inverness Medical Innovations to Develop Commercial Test to Detect Early Alzheimers Disease
2. Nautilus Neurosciences and Tribute Pharmaceuticals Announce Exclusive Canadian License for CAMBIA™ (diclofenac potassium for oral solution) for the Acute Treatment of Migraine
3. Nautilus Neurosciences and Mission Pharmacal Announce Exclusive Co-Promotion Agreement for CAMBIA™ (diclofenac potassium for oral solution) for the Acute Treatment of Migraine to the Womens Health Market
4. US WorldMeds Acquires Solstice Neurosciences
5. Intellect Neurosciences, Inc. Announces Independent Studies on Copper Binding Properties of its Lead Candidate OXIGON(TM)
6. Neurosciences Institute Discovers Drug Extends Stroke Treatment Time to 24 Hours, Repairs Brain Tissue
7. Intellect Neurosciences, Inc. and Medical Research Council Technology (U.K.) Reach Important Milestone in Generating an Alzheimers Therapeutic Antibody
8. Knopp Neurosciences Receives Orphan Designation for KNS-760704 for Treatment of ALS
9. Knopp Neurosciences Initiates Phase 1 Clinical Trial of KNS-760704 in ALS Development Program
10. Intellect Neurosciences, Inc. and CHDI, Inc. Enter Into Compound Testing Agreement to Evaluate OXIGON(TM) as a Potential Treatment for Huntington Disease
11. Intellect Neurosciences, Inc. to Present Data on Alzheimers Vaccine at 13th International Congress of Immunology Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... , April 28, 2016 ... "Global Plastic Surgery Products Market 2016-2020" report ... ) , The global plastic surgery ... of 9.47% during the period 2016-2020. , ,The growing ... leading to the growth of the market. Lasers are ...
(Date:4/28/2016)... NEW YORK , April 28, 2016  The ... reached 275 million dollars, according to Kalorama Information and ... includes typing, immunoassays and nucleic acid testing.  The healthcare ... had made progress in developing blood collection stations and ... was made in Kalorama Information,s report, Blood ...
(Date:4/28/2016)... 28, 2016 Dr. Vivek Ahuja ... and Ste phen Schmidt ... leading provider of cloud-based software solutions for life sciences, today announced ... bring a wealth of insight to a growing business.  This will ... George Phillips joined ArisGlobal in the position of ...
Breaking Medicine Technology:
(Date:5/3/2016)... ... May 03, 2016 , ... Hydra Skin Sciences, a top-rated skincare company ... a revolutionary new anti-aging skin care product that integrates Snow Algae Powder ... sold over seventy-five thousand units worldwide within the first two months of release. , ...
(Date:5/3/2016)... ... , ... Dave Newberry, broker/owner of Newberry Realty, recently announced his office will ... on Friday, May 20. “We have raised over $1,000 for the table to support ... , PICC is a local Kent, WA, clinic that cares for drug-exposed babies and ...
(Date:5/2/2016)... ... 2016 , ... RNK Products, Inc. (RNK) is beta testing ... the stethoscope stream to go over the video conferencing audio channel. This ... , Remote auscultation involves two software elements on the PC: , 1)    Network transport ...
(Date:5/2/2016)... ... , ... ProElectric Cartoon is a package of 30 hand-drawn electrifying animations made ... of electric styles including zap, sizzles, and more. Easily alter the highlights, midtones, and ... rotation, and much more. ProElectric Cartoon’s simplistic style makes it the perfect complement for ...
(Date:5/2/2016)... Texas (PRWEB) , ... May 02, 2016 , ... Pets ... As a token of appreciation, pet owners celebrate National Pet Week, which falls on ... in 2016, remind pet owners to cherish the human-animal bond and recognize responsible pet ...
Breaking Medicine News(10 mins):