Tezampanel Meets Primary Endpoint in Phase IIb Clinical Trial in Acute Migrain...(roup ofglutamate receptors referred to a...),Health

Date:10/22/2007

roup of glutamate receptors referred to as AMPA and kainate. These receptors are found in areas of the central and peripheral nervous system that are important for the transmission of pain. During a migraine attack, levels of glutamate increase and activate these receptors, facilitating the transmission of pain impulses. Tezampanel, by blocking the binding of glutamate to these receptors, is believed to inhibit the transmission of pain signals that lead to migraine headaches.

NGX426, Oral Prodrug of Tezampanel

TorreyPines is also developing NGX426, an oral prodrug of tezampanel. In an ongoing Phase I study, NGX426 appears safe and well-tolerated at doses the company believes may be effective in relieving chronic pain, including migraine pain. TorreyPines plans to initiate a Phase II study of NGX426 in acute migraine in 2008. As an oral prodrug of tezampanel, NGX426 broadens TorreyPines' portfolio by providing an additional route of administration to potentially address the varied and unmet needs of migraine and pain sufferers.

About Acute Migraine Headaches

Migraine is a debilitating neurological condition characterized by an intense and disabling episodic headache. According to the National Headache Foundation, an estimated 30 million people in the U.S. suffer from migraines. More than 50 percent of migraine sufferers endure from one to four migraine attacks per month. In addition to headache pain, migraine attacks are frequently accompanied by photophobia, phonophobia, nausea and vomiting. Although once thought to be primarily caused by vascular changes in the brain, some researchers now consider migraine a neurological disorder.

Conference Call/Webcast Information

TorreyPines will host a conference call and webcast to discuss the Phase IIb results. The call is scheduled for today, October 22nd at 9:00 A.M. Eastern time. The webcast and slides can be accessed at http
'/>"/>

SOURCE TorreyPines Therapeutics, Inc. Copyright©2007 PR Newswire. All rights reserved

1 GOOD

Page: 1 2 3 4 5 6 7 8
Related medicine technology :

1. ENDEAVOR IV Clinical Trial Meets Primary Endpoint
2. Second Phase III Study Evaluating Gileads Viread for the Treatment of Chronic Hepatitis B Virus Meets Primary Endpoint
3. Second Phase III Study Evaluating Gileads Viread for the Treatment of Chronic Hepatitis B Virus Meets Primary Endpoint
4. Neoprobe Phase 2 Lymphoseek Trial Meets Primary Endpoint
5. Phase III Study Evaluating Gileads Viread for the Treatment of Chronic Hepatitis B Virus Meets Primary Endpoint
6. SciClone and Sigma-Tau Report Thymalfasin Meets Primary Endpoint in Phase 2 Malignant Melanoma Trial
7. GlaxoSmithKline’s Hib-MenCY-TT Combination Vaccine Meets Phase II Study Endpoints of Immunogenicity and Safety Compared to Licensed Vaccines
8. YM BioSciences Reports AeroLEF Randomized Phase IIb Trial Meets Primary Endpoint in Patients with Post-Surgical Pain
9. DX-88 for Hereditary Angioedema Meets Primary and Secondary Endpoints in Phase 3 Trial (EDEMA3)
10. Alexzas AZ-004 Phase IIa Trial Meets Primary Endpoint in Treating Schizophrenic Patients With Acute Agitation
11. Replidyne Phase II Pediatric Trial Meets Primary Objective