Navigation Links
Tezampanel, TorreyPines Therapeutics' Lead Compound, Reduced Muscle Spasticity and Rigidity in Preclinical Study Conducted at University of California, San Diego
Date:10/17/2007

Data Suggest Potential for Treating Motor System Disorders

LA JOLLA, Calif., Oct. 17 /PRNewswire/-- Tezampanel, a novel small molecule currently in clinical development by TorreyPines Therapeutics, Inc. (Nasdaq: TPTX) for the treatment of acute migraine headache, was shown in an independent study to be effective in reversing or preventing muscle spasticity and rigidity in a rat model of spinal ischemia. These symptoms are commonly seen in Parkinson's disease, multiple sclerosis, cerebral palsy and other progressive motor system disorders caused by brain trauma or spinal cord injury.

In a study published in the October 17 issue of the Journal of Neuroscience, a team of international researchers found that tezampanel, identified in the study as NGX424, reduced muscle spasticity (stimulus-dependent increase in muscle tone) and rigidity (continuous stimulus-independent increase in muscle tone) in the hind legs of spinal ischemia-induced paraplegic rats. In humans with motor system disorders, muscle spasticity and rigidity, often combined with painful perception, can interfere with rehabilitation and daily activities.

The study was led by Michael P. Hefferan, Ph.D., and Martin Marsala, M.D., Anesthesiology Research Laboratory, Department of Anesthesiology, University of California, San Diego (UCSD). Neil Kurtz, M.D., President and Chief Executive Officer of TorreyPines Therapeutics, served as one of the study authors.

An AMPA/kainate receptor antagonist, tezampanel acts on glutamate receptors located in the brain and spinal cord. While essential to central nervous system function, excess glutamate production -- prompted by disease or injury -- can have pathological effects. In the study, tezam
'/>"/>

SOURCE TorreyPines Therapeutics, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
2. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
3. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
4. GTC Biotherapeutics to Webcast Corporate Presentation at the C.E. Unterberg, Towbin Emerging Growth Life Opportunities Conference
5. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
6. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
7. Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
8. Pieris Progresses Development of its Proprietary Biotherapeutics Platform: Successful Demonstration of Dual Targeting With Duocalin(R) Technology
9. Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Extension Trial with Tovaxin for Multiple Sclerosis
10. Orexigen Therapeutics to Present Data on Contrave Impact on Visceral Fat and Insulin Resistance at American Diabetes Association 67th Scientific Sessions in Chicago June 23
11. Allos Therapeutics Reports Results for Phase 3 Enrich Study of Efaproxyn in Women With Brain Metastases Originating From Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... , Aug. 20, 2014 Northstar Global ... that after months of hard work from many ... new Snorenz formulation and package design.  The new ... B-6 back into the product due to overwhelming ... lasting effects.  Snorenz Nighttime will also include these ...
(Date:8/20/2014)... , Aug. 20, 2014  The National ... the latest results achieved by the real-time, pseudoephedrine ... the National Precursor Log Exchange (NPLEx), automatically blocks ... track down meth offenders and make arrests. Data ... Kentucky blocked the sale of ...
(Date:8/20/2014)... 20, 2014  The National Association of Drug ... achieved by the real-time, pseudoephedrine (PSE) blocking system ... Log Exchange (NPLEx), automatically blocks unlawful pseudoephedrine sales ... offenders and make arrests. Data released by NPLEx ... blocked the sale of more than 19,030 ...
Breaking Medicine Technology:Northstar completes the first phase of its new retail strategy and prepares to ship reformulated Snorenz with all new packaging 2Kentucky's Stop-Sale System Achieves Significant Results In Battle Against Meth 2Missouri's Stop-Sale System Achieves Significant Results In Battle Against Meth 2
... April 27 RedVision, a national provider of real ... integrated production workflow solution for lenders, title underwriters, title agents, and ... , , ... industry compiles, prepares and delivers real property reports and title examinations. ...
... MyPunchbowl.com, the leader in start to finish party planning, ... Harry Lin , the former General Manager of Evite.com has joined ... has joined the Board of Directors. The pair joins a distinguished ... Michael Rost , PNC Equity, Lucy McQuilken , Intel ...
Cached Medicine Technology:RedVision Announces Integrated Client Workflow Platform: TitleVision2 'The Power of Two' 2MyPunchbowl Expands Leadership Team With Veterans of Evite.com and Pizza Hut 2MyPunchbowl Expands Leadership Team With Veterans of Evite.com and Pizza Hut 3
(Date:8/21/2014)... 2014 The report "Indoor ... Hybrid), Maps and Navigation, Location based analytics, ... - Worldwide Market Forecasts and Analysis (2014 ... location market into various sub-segments with an ... report also identifies the factors driving this ...
(Date:8/21/2014)... authorities need to ensure that experimental drugs to treat ... randomized controlled trials, according to a new Viewpoint, published ... 2014]. , Leading bioethicists Professor Ezekiel Emanuel, ... Annette Rid, of King,s College London, UK, outline critical ... experimental drugs are to be deployed in the Ebola ...
(Date:8/21/2014)... A mindfulness-based therapy for depression has the added ... see their family doctors, according to a new study ... and the Institute for Clinical Evaluative Sciences (ICES). ... who received mindfulness-based cognitive therapy showed a significant reduction ... compared with those who received other types of group ...
(Date:8/21/2014)... Irvine, CA (PRWEB) August 21, 2014 ... co-founder of American Corporate Health, was recently ... most influential professionals in the field of ... the National Workers’ Compensation and Occupational Medicine ... practitioners, including attorneys, physicians, nurses, case managers, ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 As part ... U.S. Pharmacopeial Convention (USP) has joined with the Alliance ... posed by the illegal online sale of medicines. , ... of medicines and foods is a core mission for ... around the world,” said Ronald T. Piervincenzi, chief executive ...
Breaking Medicine News(10 mins):Health News:Indoor Location Market Worth $3.9 Billion by 2019 - New Report by MarketsandMarkets 2Health News:Indoor Location Market Worth $3.9 Billion by 2019 - New Report by MarketsandMarkets 3Health News:Indoor Location Market Worth $3.9 Billion by 2019 - New Report by MarketsandMarkets 4Health News:The Lancet: Experimental Ebola drugs must be fairly distributed and tested ethically in clinical trials 2Health News:Mindfulness-based depression therapy reduces health care visits 2Health News:Dr. Vasili Gatsinaris Named One of the Top 50 Most Influential in Workers’ Compensation 2Health News:USP Joins Efforts to Halt Illegal Online Drug Sales 2
... Practice Guidelines (CPG) has recommended that waist circumference be ... that a national surveillance system be developed that incorporates ... ,This represents a landmark publication, as Canada is the ... guidelines to address the management and prevention of overweight ...
... body to address issues such as food quality and safety, ... ,"We have been concerned with integration of our food ... agencies, and hence we have recently enacted the Food Safety ... be administered by a single autonomous and scientific regulatory body," ...
... a heat wave with day temperatures in state capital ... shooting// up to 42 degrees Celsius. ,Roads ... Korba. In Raipur, people preferred to remain indoors while ... department has forecast a further rise in heat this ...
... agreed to lower the prices of Kaletra/Aluvia in low ... on a request from the World Health Organization’s Director-General ... the treatment of HIV-1 infected adults and children above ... antiretroviral agents. It is in a category of HIV ...
... obviously stressed. Who wouldn’t be with a daughter like Tracey! ... puffing her way through// a mountain of cigarettes three or ... Hunt, formerly Langton and Rachid) is a long-running character on ... by Anne Kirkbride since 1972. Deirdre has become synonymous with ...
... the Novartis case, the government of India is moving fast ... ,It has now been notified that all patent litigations filed ... amended Patent Act have been transferred to the Intellectual Property ... pharmaceutical companies have filed cases in High Courts and lower ...
Cached Medicine News:Health News:New Guidelines to Address Growing Obesity Epidemic 2Health News:New Guidelines to Address Growing Obesity Epidemic 3Health News:Abbott to Subsidize Price of HIV Drug 2Health News:Smoking on Television is Harmful to the Health of the Nation's Youth: BMA 2Health News:Smoking on Television is Harmful to the Health of the Nation's Youth: BMA 3Health News:Patents: Appellate Board Becomes Functional 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: