l Research. Prior to Cephalon, she served as Vice President, Clinical Research at US Bioscience Inc. and held positions of increasing responsibility within the company from 1996 to 1999. From 1995 to 1996, she was a clinical research physician at Eli Lilly U.K. and a medical director at Amgen U.K. from 1992 to 1995. Dr. Russell was trained in hematology/oncology at Royal Infirmary of Edinburgh
and at Royal Hospital for Sick Children, Edinburgh
. She received an MBChB from the University of Edinburgh, Scotland, is a member of the Royal College of Physicians, United Kingdom
and is registered with the General Medical Council, United Kingdom
Birinapant (formerly TL32711) is a small molecule peptidomimetic of SMAC (second mitochondrial-derived activator of caspases), an endogenous regulator of apoptotic cell death, that antagonizes the inhibitor of apoptosis proteins (IAPs). Birinapant is in clinical development for the treatment of solid tumors and hematological malignancies. In clinical studies to date, birinapant has been well-tolerated and exhibited suppression of IAPs and antitumor activity.
About TetraLogic Pharmaceuticals
TetraLogic Pharmaceuticals is a privately held biopharmaceutical company that focuses on the discovery and development of second mitochondrial-derived activator of caspases (SMAC) mimetics, small molecule drugs that mimic SMAC for the treatment of cancers. The company's institutional investors include Clarus Ventures, HealthCare Ventures, Quaker Partners, Novitas Capital, Nextech Invest Ltd, Hatteras Venture Partners, Pfizer Ventures, Latterell Venture Partners, the Vertical Group, Amgen Ventures, and Kammerer Associates. For additional information, please refer to the company's Web site at www.tetralogicpharma.com.
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