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TetraLogic Closes $6 Million Series C-1 Investment with Nextech Invest Ltd.
Date:5/24/2011

m the TL32711 Phase 2a clinical studies will be available during the first half of 2012.

About Apoptosis and Smac Mimetics

Apoptosis, a process of programmed cell death, is the primary way that cancer cells are destroyed by cancer therapies and the body's immune response to cancer. Apoptosis can be activated through two pathways: the extrinsic pathway, mediated by stimulation of cell death receptors binding to cellular microenvironment signals such as tumor necrosis factor alpha (TNF-a) and TNF-related apoptosis-inducing ligand (TRAIL), and the intrinsic mitochondrial apoptotic pathway, which is activated by a number of signals such as hypoxia, oxidative stress, chemotherapies and irradiation. Both pathways converge in a common pathway that ultimately leads to caspase activation and apoptosis. The inhibitor of apoptosis proteins (IAPs) block apoptosis by inhibiting caspase activation at the TNF receptor level and by directly binding to and inhibiting executioner caspases.

Smac (second mitochondrial-derived activator of caspases) is the endogenous inhibitor of IAPs that antagonizes the activity of IAPs by inducing their degradation and neutralizing their inhibitory effect on caspases.  In cancer, there is an imbalance between IAPs and Smac resulting in elevated levels of IAPs, which influences cancer survival, progression and resistance to therapy. Smac mimetics are small molecule drugs designed to mimic the action of Smac and correct the cancer imbalance. Smac mimetics bind to IAPs and block their function, thereby restoring the apoptosis pathway.  The central role between Smac and IAPs in cancer cell death renders Smac mimetics a promising new class of therapeutics that are relevant to treating all types of cancer by targeting fundamental mechanisms of cancer cell survival and resistance. Smac mimetics have been shown to neutralize IAPs in preclinical studies, and thus, overcome resistance and enable cancer cell death b
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SOURCE TetraLogic Pharmaceuticals
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