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Tengion Provides Business Update and Reports Third Quarter 2010 Financial Results
Date:11/1/2010

gression and better survival compared to the age- and disease-matched untreated control animals. In addition, blood pressure was significantly reduced in these animals.  The study is continuing as planned.
  • Also in September 2010, Tengion announced the publication of a key study in the American Journal of Physiology Renal Physiology by researchers at Tengion.  In the study, rodents with chronic kidney disease were treated with healthy kidney cells to catalyze the regeneration of functional kidney tissue and delay disease progression, as evidenced by extended survival, improved kidney filtration and reduced severity of kidney tissue pathology.
  • In addition, bioprocess work supporting the Neo-Kidney Augment program has recently been published online in the journal Tissue Engineering and will appear in an upcoming print edition.  The paper highlights new results demonstrating the Company's success in isolating, characterizing and expanding kidney cells across multiple species, including humans.  The paper also details findings that show that the Company was able to develop methods to yield distinct subpopulations of primary kidney cells that are compatible with process development and scale-up, which will be key for clinical development activities.  Not only were these findings demonstrated in normal rodent, large mammal and human kidneys, they were also successfully replicated with rodent and human tissues with advanced chronic kidney disease, including some patients with diabetes. These data show that regeneration of these cells is feasible even with source biopsies from end-stage diseased kidneys.

  • Upcoming Scientific PresentationsThe Company plans to present a poster highlighting early data from mechanism-of-action studies for the Neo-Kidney Augment program on November 19, 2010 at the American Society of Nephrology meeting in Denver, CO.  

    In addition, the Company plans to make over a do
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    SOURCE Tengion, Inc.
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