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Telik Announces the Publication of Two Reports in the Journal Of Hematology & Oncology Describing the Results of a Clinical Study of Telintra® in Combination With Revlimid® and a Genomic Study Designed to Identify Genes That Predict Response to Teli
Date:5/15/2012

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Telintra is in clinical development for the treatment of low to intermediate-1 risk MDS, where it has shown significant clinical activity, including durable red blood cell transfusion independence and multilineage responses.  Since it would be of significant clinical benefit to be able to identify patients most likely to respond to Telintra before therapy is initiated, a gene marker analysis was performed using RNA available from 30 patients enrolled in a Phase 2 Telintra clinical trial.  The Telintra response profile was found to contain two miRNAs that regulate expression of genes known to be implicated in MDS disease pathology.  In addition, pathway analysis of the response profile revealed that the genes comprising the jun-N-terminal kinase/c-JUN molecular pathway, which is known to be activated by Telintra, were under-expressed in responders and over-expressed in non-responders, providing additional support for the novel mechanism of action of Telintra and a potential basis for a companion diagnostic.

Dr. Azra Raza, Professor of Medicine and Director of the MDS Center at Columbia University Medical Center and lead investigator, stated:  "The gene expression profile shows that patients who under-express genes in the Jun kinase pathway are the ones likely to respond to Telintra.  The pathway analysis of the response profile suggests that both the biology of the disease and the mechanism of action of Telintra are positively correlated.  These exciting clinical and biologic observations provide further validation and insight into the novel mechanism of action of Telintra and its potential benefit to MDS patients." 

Background on MDS and Telintra

The myelodysplastic syndrome is a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis (blood cell production) involving one or more cell lineages (red blood cells, white blood cells, or platelets) an
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