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Telik Announces Publication of a Report of Complete Response of G-CSF Resistent Severe Idiopathic Chronic Neutropenia Following Treatment with Telintra®
Date:11/3/2011

e Idiopathic Chronic Neutropenia

Severe Chronic Idiopathic Neutropenia is a rare hematologic disorder characterized by persistent severe low white blood cell levels, leading to recurrent fevers, chronic mouth inflammation and life-threatening infections. The severity and risk of complications, including serious infections, are inversely proportional to the low white blood cell levels, with the greatest problems occurring in patients with levels of less than 500.  G-CSF has been the standard therapy for increasing white blood cell levels in these patients. A subgroup of patients does not respond to subcutaneous administration of G-CSF and patients receiving chronic G-CSF therapy may experience side effects of bone and muscle pain as well as low platelet level and enlarged spleen, complicating their therapy.

Background on Telintra

Telintra is an investigational agent in development for the treatment of a variety of neoplastic and non-neoplastic hematologic disorders, including myelodysplastic syndrome (MDS), and has demonstrated significant improvement in the induction of growth and differentiation of hematologic precursor stem cells as well as an increase in apoptosis of malignant cells.  Telintra is an inhibitor of the enzyme glutathione S-transferase P1-1 (GST P1-1), a negative regulator of JNK.  Treatment of human cells with Telintra leads to the activation of JNK, which promotes the growth and differentiation of hematopoietic stem cell precursors.  Telintra treatment has shown significant improvement in neutrophil levels in several clinical trials in MDS.  More information about Telintra may be found at www.telik.com.  

About Telik, Inc.

Telik, Inc. of Palo Alto, CA, is a clinical stage drug development company focused on discovering and developing small molecule drugs to treat cancer.  The company's most advanced drug candidate is Telintra&
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SOURCE Telik, Inc.
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2. Telik Announces Initiation of a Phase 2b Clinical Trial of Telintra® (Ezatiostat HCL) in Patients With Low to Intermediate-1 Risk Non-Deletion (5q) Myelodysplastic Syndrome
3. Telik Announces Publication in the Journal Cancer of a Phase 2 Randomized Multicenter Study of Two Extended Dosing Schedules of Oral Ezatiostat in Low to Intermediate-1 Risk Myelodysplastic Syndrome
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