Navigation Links
Telik Announces Presentation of New Data on the Characterization of Novel Ezatiostat (TELINTRA®, TLK199) Analogs at American Association for Cancer Research Annual Meeting
Date:4/5/2011

on MDS and TELINTRA

The myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis (blood cell production) involving one or more cell lineages (red blood cells, white blood cells or platelets) and a variable risk of transformation to acute myeloid leukemia (AML).  MDS becomes more common with age.  It is estimated that MDS affects approximately 300,000 people worldwide.  According to the American Cancer Society, 10,000–20,000 new cases of MDS are diagnosed each year in the United States, with survival rates ranging from six months to six years.  MDS patients often require blood transfusions to manage their disease.

There remains a critical need for effective, well tolerated therapies for MDS.  Telintra has a novel mechanism of action that inhibits an enzyme called glutathione S-transferase P1-1, which leads to activation of Jun kinase, a key regulator of cellular growth and differentiation of blood precursor cells.  Telintra has been shown to stimulate normal multilineage differentiation of blood stem cell precursors and induce cancer cell death, or apoptosis, in human leukemia cell lines.  Additional information about Telintra is available at www.telik.com.

About Telik, Inc.

Telik, Inc. of Palo Alto, CA, is a clinical stage drug development company focused on discovering and developing small molecule drugs to treat cancer.  The company's most advanced drug candidate is Telintra®, a modified glutathione analog intended for the treatment of hematologic disorders including myelodysplastic syndrome; followed by Telcyta®, a cancer activated prodrug for the treatment of a variety of cancers.  Telik's product candidates were discovered using its proprietary drug discovery technology, TRAP®, which enables the rapid and efficient discovery of small m
'/>"/>

SOURCE Telik, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Telik Announces Presentation and Webcast at 10th Annual Needham Healthcare Conference
2. Telik Announces Fourth Quarter and 2010 Year End Financial Results and 2011 Financial Guidance
3. Telik Announces Presentation and Webcast at 13th Annual BIO CEO & Investor Conference
4. Telik Announces Presentation at American Society of Hematology Annual Meeting
5. Telik Announces Third Quarter 2010 Financial Results
6. Telik Awarded $1.2 Million in Grants for Qualifying Therapeutic Development Projects
7. Telik Announces Publication of Review Focused on the Inhibition of the Enzyme GSTP1-1 as a Target for New Cancer Treatments
8. Telik Announces Publication of a Case Report of a Sustained Hematologic Response in Myelodysplastic Syndrome Following an Abbreviated Exposure to Oral Telintra(R) (Ezatiostat HCl)
9. Telik Announces Fourth Quarter and 2009 Year End Financial Results and 2010 Financial Guidance
10. Telik Announces Initiation of Phase 1 Clinical Study of Ezatiostat Hydrochloride (TELINTRA(R), TLK199) Tablets in Combination With Lenalidomide (Revlimid(R)) in Patients With Myelodysplastic Syndrome (MDS)
11. Telik Announces Third Quarter 2009 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... Ill. , July 22, 2014 ... to physicians is spreading to previously rep-friendly specialties, ... global sales and marketing consulting firm ZS Associates. ... more than 200 U.S. pharmaceutical sales teams. The ... other prescribers meet with the pharmaceutical sales reps ...
(Date:7/22/2014)... July 22, 2014  According to the American Optometric ... spend on digital devices. An AOA survey reports that ... and 17 estimate they use an electronic device for ... AOA survey of parents revealed that only 40 percent ... for that same amount of time. Eye doctors are ...
(Date:7/22/2014)... JUNCTION, N.J. , July 22, 2014  Vernalis ... the achievement of proof-of-concept (POC) for CCP-08, the ... US prescription cough cold collaboration. Under this collaboration, ... including a successful human pilot comparative study against ... of achieving POC, Vernalis will make a milestone ...
Breaking Medicine Technology:Even traditionally rep-friendly specialists will see fewer pharmaceutical sales reps this year, according to ZS Associates 2Even traditionally rep-friendly specialists will see fewer pharmaceutical sales reps this year, according to ZS Associates 3Even traditionally rep-friendly specialists will see fewer pharmaceutical sales reps this year, according to ZS Associates 4Even traditionally rep-friendly specialists will see fewer pharmaceutical sales reps this year, according to ZS Associates 5Survey Reveals Parents Drastically Underestimate the Time Kids Spend on Electronic Devices 2Survey Reveals Parents Drastically Underestimate the Time Kids Spend on Electronic Devices 3Survey Reveals Parents Drastically Underestimate the Time Kids Spend on Electronic Devices 4Third Product in Vernalis' Cough Cold Pipeline (CCP-08) Achieves Proof-of-Concept 2Third Product in Vernalis' Cough Cold Pipeline (CCP-08) Achieves Proof-of-Concept 3
... 2010 Arlington Medical Resources (AMR), a provider ... diagnostic imaging industries, finds that, in the treatment ... use of vitamin K antagonists, as a class, ... oral formulation, overall low cost and widespread inclusion ...
... 2010 DSM Pharmaceutical Products, the custom manufacturing ... license agreement with c-LEcta GmbH for proprietary screening ... to c-LEcta,s proprietary alcohol dehydrogenases for enzyme screening ... manufacturing of pharmaceutical active ingredients and intermediates. Germany-based ...
Cached Medicine Technology:Use of Vitamin K Antagonists in the Treatment of Atrial Fibrillation is Driven by the Availability of an Oral Formulation, Cost and Widespread Inclusion on Guidelines and Formularies 2DSM Expands Industrial Biocatalysis Platform With c-LEcta Agreement 2DSM Expands Industrial Biocatalysis Platform With c-LEcta Agreement 3
(Date:7/22/2014)... City, OK (PRWEB) July 22, 2014 ... the launch of the newest component of its existing ... area hospital within the regional SSM Health Care of ... affiliate health centers that shares its services with an ... primary care centers across several states. As a forward-thinking ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 DocbookMD ... process of deploying one of the largest physician-centric mobile ... ( MHMD ) in Houston. , Created by Austin-based ... the DocbookMD application will be embedded into MHMD’s Accountable ... searched for the best technology to put this capability ...
(Date:7/22/2014)... Dr. Dental is excited to announce the redesign ... in mind, one of the main differences from the old ... navigation very easy. Dr. Dental is renowned for having exceptional ... dentist affordable, convenient and fun, and the new website mirrors ... appointment scheduling system right on the home page where a ...
(Date:7/22/2014)... 22, 2014 A Florida woman has ... that alleges the death of her husband was the ... thinner, Bernstein Liebhard LLP reports. According to her complaint, ... for the Southern District of Florida on June 23rd, ... suffered a subdural hemorrhage the following June. Despite emergency ...
(Date:7/22/2014)... hysterectomy using electric power morcellation, uterine cancers were present ... the procedure, according to a study published by ... in which the uterus is fragmented into smaller pieces, ... Despite the commercial availability of electric power morcellators for ... at the time of electric power morcellation (in this ...
Breaking Medicine News(10 mins):Health News:St. Anthony Hospital Expands Its Telemedicine Program with Telepsychiatry 2Health News:St. Anthony Hospital Expands Its Telemedicine Program with Telepsychiatry 3Health News:Memorial Hermann Physician Network Launches Physician Mobile Communication Solution Throughout Houston 2Health News:Memorial Hermann Physician Network Launches Physician Mobile Communication Solution Throughout Houston 3Health News:Memorial Hermann Physician Network Launches Physician Mobile Communication Solution Throughout Houston 4Health News:Dr. Dental Reveals Exciting New Website 2Health News:Xarelto Lawsuit Filed by Florida Woman Alleges Uncontrollable Bleeding Led to Husband’s Death, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuit Filed by Florida Woman Alleges Uncontrollable Bleeding Led to Husband’s Death, Bernstein Liebhard LLP Reports 3Health News:Study examines presence of uterine cancers at the time of hysterectomy using morcellation 2
... , March 10 Smart Balance, Inc. (Nasdaq: SMBL ) announced today that Stephen Hughes , Chairman and Chief Executive Officer of Smart Balance, ... Tuesday, March 16, 2010 . , ... , , ... ...
... technological revolution, the "light fantastic" continues to impact people,s ... and performing intricate surgery. As the golden anniversary of ... 7th, Chemical & Engineering News (C&EN), ACS, weekly newsmagazine, ... exciting future of this amazing invention. C&EN ...
... may someday extend men,s lives, , WEDNESDAY, March 10 ... in treating late-stage prostate cancer, it often results in ... to such therapy. , Now, however, researchers working with ... the secondary tumors gain their resistance -- a finding ...
... ... investment banking and business development to LeveragePoint,s Board of Directors. , ... Cambridge, MA (PRWEB) March 10, ... Value Management software for marketing and sales, today announced that entrepreneurial advisor and seasoned ...
... ... ... , , , , ... ...
... , ... ... , , , ... ...
Cached Medicine News:Health News:Smart Balance to Present at Roth Growth Stock Conference 2Health News:Scientists Find Key to Hormone-Resistant Prostate Tumors 2Health News:Scientists Find Key to Hormone-Resistant Prostate Tumors 3Health News:Peyton Marshall Joins LeveragePoint Innovations Board 2Health News:Peyton Marshall Joins LeveragePoint Innovations Board 3Health News:Maryland Legislation Introduced to Prohibit Indoor Tanning for Minors 2Health News:Maryland Legislation Introduced to Prohibit Indoor Tanning for Minors 3Health News:Maryland Legislation Introduced to Prohibit Indoor Tanning for Minors 4Health News:Maryland Legislation Introduced to Prohibit Indoor Tanning for Minors 5Health News:Maryland Legislation Introduced to Prohibit Indoor Tanning for Minors 6Health News:Celebrate National Nutrition Month and St. Patrick's Day, Go Green With Pistachios - The Only Green Nut! 2Health News:Celebrate National Nutrition Month and St. Patrick's Day, Go Green With Pistachios - The Only Green Nut! 3Health News:Celebrate National Nutrition Month and St. Patrick's Day, Go Green With Pistachios - The Only Green Nut! 4Health News:Celebrate National Nutrition Month and St. Patrick's Day, Go Green With Pistachios - The Only Green Nut! 5
... Test is an in vitro diagnostic screen ... Changes in FSH levels in human urine ... stages of menopause. The InstaCheck® Menopause Predictor ... qualitative result and is intended for over- ...
... fine urine chemistry reagent strips. Since ... strips from start to finish, we ... prices compared to other major producers ... urine reagent strips are for the ...
... a wealth of benefits to healthcare professionals and ... measure a complete lipid profile and glucose, ALT, ... in 5 minutes per test cassette (6 minutes ... demo, click here ., ,The accuracy, speed ...
... delivers an unmatched combination of speed, accuracy and ... and monitoring a patient's A1C levels. To ... ., ,The CLIA-waived Cholestech GDX requires only a ... than 5 minutes. The system is a proven ...
Medicine Products: