Navigation Links
Telik Announces Presentation of New Data on the Characterization of Novel Ezatiostat (TELINTRA®, TLK199) Analogs at American Association for Cancer Research Annual Meeting
Date:4/5/2011

PALO ALTO, Calif., April 5, 2011 /PRNewswire/ -- Telik, Inc. (Nasdaq: TELK) today presented data at the 102nd American Association for Cancer Research (AACR) Annual Meeting in Orlando, Florida on a group of second generation analogs of ezatiostat, the most clinically advanced product in development at Telik.  Ezatiostat is the first inhibitor of glutathione-S-transferase P1-1 (GST P-1), a validated enzyme target in Myelodysplastic Syndrome (MDS), to successfully complete a Phase 2 clinical trial.  The efficacy and tolerability observed with ezatiostat in several Phase 1 and Phase 2 clinical trials supported the initiation of the analog program to identify potential follow-on drug candidates.  The structure-activity relationships for the most compelling of these analogs are presented in the AACR poster, entitled Synthesis and Biochemical Characterization of Novel Analogs of Ezatiostat Hydrochloride (TELINTRA®, TLK199) by Danying Cai et al.  A copy of the poster will be available on the Telik website at www.telik.com.

A series of diacid ezatiostat analogs bearing different substituents on the cysteinyl sulfur were synthesized using computer aided drug design and TRAP®, a proprietary drug discovery technology, to improve the inhibitory potency and selectivity for the target enzyme GST P1-1.  Substitutions resulted in a 30- to 130-fold improvement in in vitro potency against GST P1-1 and 3- to 10-fold higher selectivity relative to other isoforms.  

The analogs exhibited potent binding and inhibition of the drug target, GST P1-1, leading to activation of the signaling molecule Jun kinase.  Like ezatiostat, the analogs induced programmed cell death, or apoptosis, of human leukemia cells as well as the growth and differentiation of normal blood stem cells, lead
'/>"/>

SOURCE Telik, Inc.
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine technology :

1. Telik Announces Presentation and Webcast at 10th Annual Needham Healthcare Conference
2. Telik Announces Fourth Quarter and 2010 Year End Financial Results and 2011 Financial Guidance
3. Telik Announces Presentation and Webcast at 13th Annual BIO CEO & Investor Conference
4. Telik Announces Presentation at American Society of Hematology Annual Meeting
5. Telik Announces Third Quarter 2010 Financial Results
6. Telik Awarded $1.2 Million in Grants for Qualifying Therapeutic Development Projects
7. Telik Announces Publication of Review Focused on the Inhibition of the Enzyme GSTP1-1 as a Target for New Cancer Treatments
8. Telik Announces Publication of a Case Report of a Sustained Hematologic Response in Myelodysplastic Syndrome Following an Abbreviated Exposure to Oral Telintra(R) (Ezatiostat HCl)
9. Telik Announces Fourth Quarter and 2009 Year End Financial Results and 2010 Financial Guidance
10. Telik Announces Initiation of Phase 1 Clinical Study of Ezatiostat Hydrochloride (TELINTRA(R), TLK199) Tablets in Combination With Lenalidomide (Revlimid(R)) in Patients With Myelodysplastic Syndrome (MDS)
11. Telik Announces Third Quarter 2009 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... , 21. Mai 2013 ... die die Firmen OMNIlife science® Inc., Enztec Ltd. ... hat zwei neue, erfahrene Mitglieder in die ... , eine erfahrene Führungspersönlichkeit aus der Orthopädie, ... David Johnson , anerkannter Experte ...
(Date:5/21/2013)... mayo de 2013 La junta directiva ... incluyen OMNIlife science®, Inc., Enztec, Ltd. y Praxim, SA, ... junta. Guy Mayer, un ejecutivo ortopédico experimentado, será vicepresidente ... Johnson , un experto refutado en dispositivos ... de unirse a OSI como presidente de la ...
(Date:5/21/2013)... Calif. , May 21, 2013 RenovoRx ... prestigious 2013 TiE50 "Top Startup" Award at TiEcon 2013, ... innovation, strong management team and quality of entrepreneurial ideas. ... at the Santa Clara Convention ... highly influential list of the most enterprising startup companies ...
Breaking Medicine Technology:Orthopaedic Synergy Inc. meldet bedeutenden Zuwachs im Vorstand 2Orthopaedic Synergy Inc. meldet bedeutenden Zuwachs im Vorstand 3Orthopaedic Synergy, Inc. anuncia nuevas incorporaciones a la junta directiva 2Orthopaedic Synergy, Inc. anuncia nuevas incorporaciones a la junta directiva 3RenovoRx Named Winner of 2013 TiE50 "Top Startup" 2
... Arbor Pharmaceuticals announced today that it has filed ... Food and Drug Administration (FDA).  The recently filed product ... which provides seven years of market exclusivity. In addition, ... this product primarily due to the safety advantages it ...
... MADISON, Wis., Dec. 1, 2011 Novelos Therapeutics, Inc. ... treatment and diagnosis of cancer, today announced the pricing of ... unit for gross proceeds of $5,904,000.  Each unit consists of ... one share of common stock.  The warrants will have an ...
Cached Medicine Technology:Arbor Pharmaceuticals Announces Filing of First NDA 2Novelos Therapeutics Prices $5.9 Million Public Offering 2
(Date:5/21/2013)... Calabash, NC (PRWEB) May 21, 2013 ... Lodges is synonymous with comprehensive travel guides. Brunswick Plantation ... play golf packages that include access to 27 holes ... available golf courses in North Carolina, knowing the ... Resorts and Lodges takes away the overwhelming task of ...
(Date:5/21/2013)... (PRWEB) May 22, 2013 About one ... the Fertility Clinics industry one of the ... assists patients who are unable to conceive naturally through ... popular of which is in-vitro fertilisation (IVF) cycles. Over ... cycles in Australia has increased by 4.4% per annum ...
(Date:5/21/2013)... Steven Reinberg HealthDay Reporter , , TUESDAY, May ... a major cause of sleep apnea in children, and ... learning for these kids, it did help them with ... finds. Sleep apnea is a condition that causes ... a greater improvement in sleep with the surgery, and ...
(Date:5/21/2013)... University of Iowa,s vice president for research and ... exascale computing, the next generation of supercomputers designed ... to the human mind. , Daniel Reed will ... of the House Subcommittee on Energy, titled, "America,s ... begins at 10 a.m. in Room 2318 of ...
(Date:5/21/2013)... Norton HealthDay Reporter , , TUESDAY, May 21 ... two genes may be at increased risk of suffering ... The researchers hope they can use the findings ... pregnant women who are vulnerable to postpartum depression, which ... study, reported in the May 21 issue of the ...
Breaking Medicine News(10 mins):Health News:Brunswick Plantation & Golf Resort Named in Top 10 Golf Resorts in North Carolina 2Health News:Fertility Clinics in Australia Industry Market Research Report Now Available from IBISWorld 2Health News:Fertility Clinics in Australia Industry Market Research Report Now Available from IBISWorld 3Health News:Removing Tonsils Helps Kids With Sleep Apnea, Study Finds 2Health News:Removing Tonsils Helps Kids With Sleep Apnea, Study Finds 3Health News:Iowa VP for Research addresses next-generation supercomputers at congressional hearing 2Health News:Genes May Boost Woman's Risk of Postpartum Depression 2Health News:Genes May Boost Woman's Risk of Postpartum Depression 3
... FUND RESEARCH TO CURE CANCER IN ... DOGS - RESEARCH ALSO BENEFITING HUMANS, DENVER, Jan. 18 ... dogs and or very special humans in your life.,Morris Animal Foundation ... contributing $50 or more to the MAF canine,cancer cure research effort. ...
... LifeSync Corporation is,pleased to announce the appointment of ... McLane comes to LifeSync Corporation after,seven years at ... she,most recently held the position of Executive Director ... McLane spent over 13,years at C.R. Bard in ...
... by Christian Rocker and Top ,Clean, Comedian Round Out the All-Star ... ... 18 Our Savior Lutheran Church,announced today an all-star line-up for its ... Sure to satisfy all in,attendance, LoveFest offers its most diverse casting to ...
... dual implantation of radioactive seeds and chemotherapy wafers ... led by specialists at the Neuroscience Institute at ... , The study, published in the February issue ... treated with simultaneous implantation of radioactive seeds and ...
... are aimed at getting action from Cardinal George and Public Official ... ... 17 Three years ago, health care activist,Joe Novak -- during a ... end the abuses of not-for-profit health,care systems, especially those that are Catholic., ...
... Medical,Center has held extensive settlement discussions with the Public ... their apparent negotiating,tactic we remain optimistic that these discussions ... The filing of a lawsuit was unnecessary given the ... not receive any document outlining,Mr. Olvera,s specific claims until ...
Cached Medicine News:Health News:Unique Gift for Valentine's Day: Canine Cancer Campaign Customized Dog Tag - for Your Dog or as a Beautiful Piece of Jewelry for a Special Human 2Health News:LifeSync Corporation Appoints Nancy McLane as Senior Vice President Operations 2Health News:LoveFest 6 Taps Hollywood Actress to Headline Annual Abstinence Conference 2Health News:Combined radiation seed, chemotherapy wafer implants show promise in treating cancerous brain tumors 2Health News:Ad Campaign Targets Abuses by Not-For-Profits 2Health News:Hollywood Presbyterian Medical Center Responds to ACLU Lawsuit 2
... The Eppendorf Reference Series 2000 Pipette is ... stroke, a compact and robust design, and ... is used to operate the measuring stroke ... tip. Product features:Eppendorf "pipette/tip" system ensures utmost ...
... The Eppendorf Reference Series 2000 Pipette is ... stroke, a compact and robust design, and ... is used to operate the measuring stroke ... tip. Product features:Eppendorf "pipette/tip" system ensures utmost ...
Inquire...
... The Eppendorf Reference Series 2000 Pipette ... smooth stroke, a compact and robust design, ... button is used to operate the measuring ... the tip. Product features:Eppendorf "pipette/tip" system ensures ...
Medicine Products: