Navigation Links
Telik Announces Preclinical Data Demonstrating Anti-Cancer Activity of Dual Inhibitors of Aurora Kinase and VEGFR2
Date:10/25/2007

PALO ALTO, Calif., Oct. 25 /PRNewswire-FirstCall/ -- Telik, Inc. (Nasdaq: TELK) reported positive preclinical data from its ongoing program to develop novel small molecule inhibitors of validated cancer targets including aurora kinases and VEGFR2. The data were presented today at the AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics in San Francisco.

Aurora kinases are enzymes that play a key role in mitosis, or cell division. They are over-expressed in many human cancers, including breast, colon, pancreas, prostate and thyroid cancer, and are associated with carcinogenesis. Several aurora kinase inhibitors are currently under clinical evaluation for the treatment of cancer.

The VEGF receptor 2 (VEGFR2/KDR/Flt-1), a clinically validated target, plays a pivotal role in controlling angiogenesis and metastasis. A single agent that targets both aurora kinases and VEGFR2 may offer advantages of simultaneously attacking the ability of cancer cells to grow and divide while starving existing tumors of needed blood supply.

Telik scientists have identified a class of selective small molecule inhibitors of aurora kinase A and B and VEGFR2. Treatment of human colorectal cancer cells with two of these inhibitors, A60 and EA19, prevented cell division, ultimately leading to cancer cell apoptosis (programmed cell death). These same compounds are potent inhibitors of VEGF-dependent human endothelial cell proliferation. These agents demonstrated significant inhibition of tumor growth in a standard xenograft model of human colorectal cancer.

"These data support the continued development of aurora kinase and VEGFR2 inhibitors," said James G. Keck, Ph.D., vice president, biology research. "We
'/>"/>

SOURCE Telik, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Telik Reports Positive Data Demonstrating Synergy in Combination and Highly Statistically Significant Effect of Telcyta as Maintenance Therapy in First-Line Non-Small Cell Lung Cancer
2. Telik Announces Telcyta Clinical and Preclinical Presentations at AACR Meeting
3. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
4. Sygnis Pharma AG announces date for presentation of clinical results
5. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
6. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
7. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
8. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
9. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
10. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
11. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... , July 11, 2014 /PRNewswire-iReach/ -- VAPETEK™, ... a vegetable-glycol solution for use in portable vaporizers, ... the active ingredients in cannabis, cannabidiol offers consumers ... vaporizer devices, and other vaporizer technology. ... Cannabis naturally contains 483 different compounds which are ...
(Date:7/11/2014)... July 11, 2014 Patient engagement has ... consequently, organizations are turning to an assortment of ... As part of this evolving approach to patient ... communicate and engage patients throughout their experiences with ... empowerment. By mapping the patient journey and employing ...
(Date:7/11/2014)... July 11, 2014 The consumer marketing ... across industry sectors to better identify winning tools ... to engage with and understand consumers, as new ... make critical purchasing decisions. According ... LLC, one area where organizations can observe a ...
Breaking Medicine Technology:VAPETEK Releases CBD-Infused eLiquid For The Consumer Market 2New Study Uses Six-Step Patient Journey as Framework for Consumer-Focused Marketing Opportunities 2New Technologies Transforming Consumer Marketing Research Playbook 2
... Echo Therapeutics, Inc. (OTC Bulletin Board: ... System as a non-invasive, wireless, transdermal continuous glucose monitoring ... delivery, today announced that it is beginning a development ... continuous lactate monitoring to be used in critical care ...
... American Medical Systems® (AMS) (Nasdaq: ... therapies for both male and female pelvic health, today ... study of the Elevate® Apical and Posterior Prolapse Repair ... to quantify, describe, and stage pelvic support, was implemented ...
Cached Medicine Technology:Echo Therapeutics Initiates Needle-Free Biosensor Program for Continuous Lactate Monitoring 2Echo Therapeutics Initiates Needle-Free Biosensor Program for Continuous Lactate Monitoring 312-Month Study Reports Efficacy Rates for AMS' Elevate Apical and Posterior Prolapse Repair System 2
(Date:7/12/2014)... Recently, Fadhits.com, a well-known wedding dress manufacturer and ... graduation dresses to its product line. In addition, the ... It wants to bring more benefits for its loyal fans. ... discounted prices, up to 72% off. , As a leader ... Its online shop is a good place for ladies who ...
(Date:7/12/2014)... July 13, 2014 Recently, iFitDress.com, one of ... selection of red evening gowns . What’s more, all ... 56% off. , The company’s senior spokesman states, “We are ... on our website is an enjoyable shopping experience. In addition ... our online store, low prices do not always mean bad ...
(Date:7/12/2014)... 2014 The Chicken Egg Production ... five years, buoyed by stable demand for industry products ... “Eggs are a relatively affordable staple for most families ... generally grows in line with the size of the ... demand for new specialty egg products with enriched qualities, ...
(Date:7/12/2014)... Passenger Information System market is estimated to grow from ... at an expected CAGR of 26.5% for the period ... in North America is well developed and network infrastructure ... the region. The growing ridership figures in public transport ... driving the North American Passenger Information System market at ...
(Date:7/12/2014)... Fresh off their respective performances in the 2014 World Cup, ... at Sun Life Stadium in an international friendly. The World ... stars in the world of football in Colombian and Brazilian ... some of the best talent in the world in early ... team in the world according to the Fédération Internationale de ...
Breaking Medicine News(10 mins):Health News:New Collection of Long Graduation Dresses Revealed by Fadhits.com 2Health News:Discounted Red Evening Gown Announced by iFitDress.com 2Health News:Chicken Egg Production in Canada Industry Market Research Report Now Available from IBISWorld 2Health News:Chicken Egg Production in Canada Industry Market Research Report Now Available from IBISWorld 3Health News:North America Passenger Information System (ICT) Market worth $5,486.88 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Passenger Information System (ICT) Market worth $5,486.88 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Passenger Information System (ICT) Market worth $5,486.88 Million by 2019 - New Report by MicroMarket Monitor 4Health News:Brazil Vs. Colombia Tickets Sun Life Stadium: Ticket Down Slashes Ticket Prices for Friendly Match Between Colombia and Brazil 2Health News:Brazil Vs. Colombia Tickets Sun Life Stadium: Ticket Down Slashes Ticket Prices for Friendly Match Between Colombia and Brazil 3
... With Food Prices on the Rise New Tools to Help ... Personal finance expert Suze Orman,is the latest celebrity to join ... in their health. With rising food costs, many,families are economizing ... is nutrition. At about 25 cents per 8 ounce glass, ...
... Do Not Feel Knowledgeable About Their,Cancer Risks and Justifies ... and Entertain, LOS ANGELES, Sept. 29 Olympic ... and Nastia Liukin, along with Team USA,will join with ... national network,television special, Frosted Pink with a Twist, in ...
... in outcomes, but offers no concrete answers , , MONDAY, Sept. ... ZIP codes are more likely to die after surgery than ... research. , The study analyzed death rates among more than ... high-risk heart or cancer surgeries between 1999 and 2003. ...
... National initiative launched to support CMS, hospital-acquired,conditions ... Today the National Business,Coalition on Health ... Centers,for Medicare and Medicaid Services, (CMS) efforts ... for specific "Never Events" -- serious and,costly ...
... cases, unproven ,therapies, can be dangerous, experts say , , ... turn to the Internet as a source of information ... are betrayed by purveyors of so-called cancer "cures" that ... five companies were charged with making false and misleading ...
... readers of improper removal of asbestos in St. Louis that may ... The city used an unapproved "wet method" of removing asbestos fibers, ... evaporates. , ... Denver, CO (PRWEB) September 29, 2008 ...
Cached Medicine News:Health News:Suze Orman Joins got milk? Milk Mustache Campaign: New Ad Encourages Families To Invest in Milk's Nutritional Assets 2Health News:Suze Orman Joins got milk? Milk Mustache Campaign: New Ad Encourages Families To Invest in Milk's Nutritional Assets 3Health News:Video: 2008 US Olympic Gymnastic Superstars Join Today's Top Music Icons for Women's Cancer Awareness Network Special, Frosted Pink with a Twist 2Health News:Video: 2008 US Olympic Gymnastic Superstars Join Today's Top Music Icons for Women's Cancer Awareness Network Special, Frosted Pink with a Twist 3Health News:Video: 2008 US Olympic Gymnastic Superstars Join Today's Top Music Icons for Women's Cancer Awareness Network Special, Frosted Pink with a Twist 4Health News:Seniors in Poor Areas More Likely to Die After Surgery 2Health News:National Business Coalition on Health Endorses New CMS 'Never Events' Policy 2Health News:National Business Coalition on Health Endorses New CMS 'Never Events' Policy 3Health News:National Business Coalition on Health Endorses New CMS 'Never Events' Policy 4Health News:Scams and Shams That Prey on Cancer Patients 2Health News:Scams and Shams That Prey on Cancer Patients 3Health News:LegalView Reports Cancer Risk for St. Louis Residents After Unapproved Asbestos Removal During Demolition 2Health News:LegalView Reports Cancer Risk for St. Louis Residents After Unapproved Asbestos Removal During Demolition 3
Blunt tipped forceps wlth a small grasping platform on each tip. For grasping fine membranes or grasping membranes adherent to the retinal surface....
Blunt tipped forceps with a smooth, pliable silicone coating on the entire interior surface of the tip. For removal of foreign bodies or atraumatic tissue grasping....
Blunt tipped forceps with small, slightly rounded tips angled perpendicular to the shaft. For grasping peripheral membranes....
Blunt tipped forceps with small, slightly pointed grasping platforms on each tip. For general purpose (fine) membrane grasping and grasping membranes adherent to the retlnal surface....
Medicine Products: