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Telik Announces Fourth Quarter and 2011 Year End Financial Results and 2012 Financial Guidance
Date:2/23/2012

year ended December 31, 2011, compared with 2010, were primarily due to lower facilities, headcount and clinical development expenses.

At December 31, 2011, Telik had $11.7 million in cash, cash equivalents, restricted cash and investments, compared with $24.1 million at December 31, 2010.

2011 Highlights

  • Announced positive Phase 1 Results of a Multicenter Study of TELINTRA in Combination with Revlimid® (Lenalidomide) in Patients with Myelodysplastic Syndrome or MDS.  In this study, the combination was well tolerated and provided a unique profile of activity with platelet transfusion independence and trilineage and bilineage responses, which was also seen with single-agent TELINTRA. 
  • Announced results of Genetic Signature Studies of Myelodysplastic Syndrome Patients Likely to Respond to TELINTRA at the Annual Meeting of the American Society of Hematology. This work was conducted in collaboration with investigators at Columbia University Medical School and at the Broad Institute of MIT and Harvard University. Pathway analysis of the expression data confirmed that a c-Jun N-terminal kinase (JNK) gene set was consistently under-expressed in the pre-therapy bone marrow mononuclear cells of responders and over-expressed in non-responders.
  • Initiation of a Phase 2 Clinical Trial of TELINTRA in patients with Revlimid® Refractory or Resistant Deletion 5q Myelodysplastic Syndrome. The primary objective is to determine the hematologic improvement-erythroid (HI-E) response rate as measured by transfusion reduction or independence, in accordance with the International Working Group MDS 2006 criteria. Secondary objectives include determination of the hematologic improvement-neutrophil (HI-N) and hematologic improvement-platelet (HI-P) response rates, and safety.
  • Initiation of a Phase 2b Clinical Trial of TELINTRA in Patients With Low to Intermediate-1 Risk Non-Deletion (5q) Myelodysplastic Syndrome. The prima
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  • SOURCE Telik, Inc.
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