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Telik Announces Fourth Quarter and 2010 Year End Financial Results and 2011 Financial Guidance
Date:2/22/2011

nted in Japan and Canada and one for the liposomal formulation of TELINTRA granted in Canada. Three other patents covering novel TELINTRA analogs were granted in Singapore and Chile.
  • Publication of a review in the journal, Cell Death and Differentiation: Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death. This review describes recent advances in the understanding of the important role that the enzyme GSTP1-1 plays in the progression of cancer and other diseases associated with increased cell proliferation. TELINTRA, inhibitor of GSTP1-1, has recently been reported to show positive results in a Phase 2 trial in patients with MDS, a disease characterized by disordered cell proliferation and differentiation.
  • Publication of a case report by Quddus et al., Oral Ezatiostat Hydrochloride (TELINTRA®) and Myelodysplastic Syndrome (MDS): A case report of sustained hematologic response following an abbreviated exposure Journal of Hematology & Oncology 2010, 3:16. This case report describes a patient who experienced a sustained hematologic response in all three blood cell lines continuing for over a year, after an abbreviated course of oral TELINTRA received while on the current Phase 2 Study in Low to Intermediate-1 Risk MDS.

    • In 2011, Telik is focusing its resources on: (1) advancing the clinical development of TELINTRA in MDS including the completion of the ongoing Phase 1 TELINTRA combination trial with lenalidomide, (2) seeking corporate partnerships for development and commercialization of its drug product candidates, (3) advancing its leading preclinical oncology drug candidates and (4) supporting TRAP® research collaborations.

    Financial Outlook

    For the full year 2011, Telik anticipates total operating costs and expenses to be in the range of $13.0 million to $15.0 million, which includes stock-based compensation expense of approximately $1.3 millio
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