Navigation Links
Telik Announces Ezatiostat (Telintra®) Preclinical Presentation at the 2011 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
Date:11/1/2011

PALO ALTO, Calif., Nov. 1, 2011 /PRNewswire/ -- Telik, Inc. (Nasdaq: TELK) announced today the presentation of mechanistic studies on Telintra and related analogs at the 2011 Meeting of the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in San Francisco, California.  Details of the presentation are as follows:


  • Novel Ezatiostat analogues disrupt binding of GSTP1 to all three major MAP kinases (JNK, ERK and p38) and exhibit context-dependent antitumor activity; Ali-Osman, F., Okamura, T., Turley, R., Barker, A.,  Keck, J.,  Laborde, E.,  Cai, D.,  Macsata, R.Abstract B229 – PO 70, Therapeutic Agents: Small Molecule Kinase Inhibitors 2, Monday, November 14, 12:30-2:30 PM and 6:00-7:30 PM.These studies were conducted by Professor Francis Ali-Osman, Director, Experimental Therapeutics Program, Duke Comprehensive Cancer Center, and expand our understanding of the novel mechanism of action of Telintra.  Telintra and related analogues, through their inhibition of the enzyme GSTP1, were able to affect the activity of all three major MAP kinases, signaling proteins that are critical for the control of cellular growth, differentiation and apoptosis.  Significant anti-tumor activity was also observed in human cancer cells derived from brain cancer, breast cancer and melanoma.  Telintra has demonstrated positive clinical activity in patients with myelodysplastic syndrome (Blood 2009, 113[26]:6533-6540; Cancer 2011, doi: 10.1002/cncr.26469), and is currently in clinical development (Clintrials.gov).

    About Telik

    Telik, Inc. of Palo Alto, CA, is a clinical stage drug development company focused on discovering and developing small molecule drugs to treat cancer.  The company's most advanced drug candidate is Telintra, a modified glutathione an
    '/>"/>


  • SOURCE Telik, Inc.
    Copyright©2010 PR Newswire.
    All rights reserved

    Page: 1 2

    Related medicine technology :

    1. Telik Announces Presentation of Preclinical Data on Dual Inhibitors of Aurora Kinases and VEGFR2
    2. Telik Announces Preclinical Data Demonstrating Anti-Cancer Activity of Dual Inhibitors of Aurora Kinase and VEGFR2
    3. Telik Announces Telintra Presentation at American Society of Hematology Annual Meeting
    4. Telik Announces Initiation of Two Phase 2 Randomized TELINTRA Studies
    5. Teliks Proteasome Inhibitor Program Meets a Preclinical Development Milestone
    6. Telik Announces Presentation at ASCO Annual Meeting
    7. Telik Announces Publication of Positive Phase 1 Results of a Multicenter Study of Ezatiostat Hydrochloride (TELINTRA(R), TLK199) Tablets In Patients With Myelodysplastic Syndrome
    8. Telik Announces Publication of Positive Phase 1-2a Results of a Multicenter Study of TELCYTA(R) in Combination With Carboplatin and Paclitaxel in Patients With Advanced Non-Small Cell Lung Cancer
    9. Telik Announces Initiation of Phase 1 Clinical Study of Ezatiostat Hydrochloride (TELINTRA(R), TLK199) Tablets in Combination With Lenalidomide (Revlimid(R)) in Patients With Myelodysplastic Syndrome (MDS)
    10. Telik Announces Third Quarter 2009 Financial Results
    11. Telik Announces Fourth Quarter and 2009 Year End Financial Results and 2010 Financial Guidance
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:3/27/2015)... -- Levi & Korsinsky announces it has commenced an ... concerning possible violations of federal securities laws. The investigation ... with its study of the drug OHR-102. To obtain ... Joseph E. Levi, Esq. either via email ... 363-7500, toll-free: (877) 363-5972. Levi & Korsinsky ...
    (Date:3/27/2015)... 2015 Dynatronics Corporation (NASDAQ: DYNT ) today ... to the Company,s Board of Directors effective March 23, 2015, ... 2014 of board member Joseph Barton .  ... Board of Directors represents an important step forward for the ... of Dynatronics.  "Rich is a proven leader and is well-known ...
    (Date:3/27/2015)... , March 27, 2015 Biopharmaceutical ... The biopharmaceutical industry comes out on top as the ... a new report  from ndp│analytics. According to the  ... development (R&D) investment over the last decade, accounting for ... A Short Video on Medicare ...
    Breaking Medicine Technology:Dynatronics Announces Appointment of Richard J. Linder to Board of Directors 2Week in Review: The Latest from PhRMA 2
    (Date:3/28/2015)... 2015 Could genetic code determine someone’s ... study by researchers at the Harvard T.H. Chan ... support of the Coffee and Caffeine Genetics Consortium and ... past fall, the study—one of several recent HSPH investigations ... from more than 120,000 regular coffee drinkers of European ...
    (Date:3/28/2015)... The California-based leading wig brand UniWigs has prepared ... UniWigs during the Easter Holidays from today until April ... April Fools’ Day. , As the winter fades and ... Easter Festival, with religious origins to countries in Europe ... Christmas. The best wig provider, UniWigs, would like to ...
    (Date:3/28/2015)... Pitching speed, player’s height, and pitching for multiple teams ... according to new research released today at the American Orthopaedic ... “Our findings indicate that a 10 inch increase in height ... history of injury, a 10 mile per hour increase in ... history of injury, and playing for more than one team ...
    (Date:3/28/2015)... 2015 Genomic medicine experts have sequenced ... for the first time, key information for understanding and ... the newly posted story on the Surviving Mesothelioma ... British Columbia, the British Columbia Cancer Agency, and PhenoPath ... underlying molecular alterations and mutations that can lead to ...
    (Date:3/28/2015)... The "Petrick Sustainable Health System" ... 18 years of research and experience with patients from ... Jon Petrick is excited to be launching his breakthrough ... immediate benefits of this radical new system are increased ... of the immune system, faster healing of injuries, rapid ...
    Breaking Medicine News(10 mins):Health News:How Coffee Habits Relate to Our Genetic Code and Enhancing the Caffeine Experience 2Health News:How Coffee Habits Relate to Our Genetic Code and Enhancing the Caffeine Experience 3Health News:UniWigs Is Sending Out Mysterious Gifts During the Easter Holidays 2Health News:Researchers Highlight Shoulder and Elbow Injury Possibility in Youth Players 2Health News:New Genomics Research May Help Doctors Tailor Mesothelioma Treatment, According to Surviving Mesothelioma 2Health News:Celebrity Chiropractor Jon Petrick to Release Sustainable Health System this Summer 2
    ... Heart disease, stroke, cancer, and diabetes are ... These conditions cause extreme human suffering, and ... their families as well as on our severely ... (ACE) Study, an ongoing collaboration between the Centers ...
    ... have identified a protein that appears to play a ... cancer cells, especially androgen-independent prostate cancer cells. The study ... . , They also found that prostate cancer cells ... prostate cells, according to Andrea Morrione, Ph.D., an associate ...
    ... Networking Site for Physicians Offers Secure Message ... Md., Feb. 26 Human Science, Inc. ... today announced the launch of an innovative ... and coordinate patient care in a secure ...
    ... 26 Orthopaedic surgeon Michael L. Parks, MD, was ... American Academy of Orthopaedic Surgeons (AAOS) ( http://www.aaos.org/ ... He will serve the Academy as Member-at-Large for ... in the reconstruction of arthritic conditions affecting the hip ...
    ... common conditionLAS VEGAS, Feb. 26 ... "wear and tear" arthritis. It can affect any ... A clinical practice guideline for the treatment of ... 2009 Annual Meeting of the American Academy of ...
    ... Systems Wellness Program Inspires Long-Term Physical ... With the warm weather beckoning everyone ... ( www.HealthEnhancementSystems.com ) corporate wellness ... ( www.springintomotiontoday.com/?from=pr_nw_090219 ), encourages participants to ...
    Cached Medicine News:Health News:The Catalyst Foundation's Groundbreaking ACE Study-Based Services Bring Transformational Change to Healthcare 2Health News:Proepithelin encourages cell growth and migration in prostate cancer 2Health News:Human Science, Inc. Launches PatientCarenet.Org 2Health News:Human Science, Inc. Launches PatientCarenet.Org 3Health News:Michael L. Parks, MD, Elected to the American Academy of Orthopaedic Surgeons Board of Directors 2Health News:An Orthopaedic Roadmap for Osteoarthritis of the Knee 2Health News:An Orthopaedic Roadmap for Osteoarthritis of the Knee 3Health News:Rejuvenating Fitness Program Motivates Participants to Spring Into Motion 2
    ... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
    ... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
    ... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
    ... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
    Medicine Products: