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Technology Collaboration Between New England Biolabs and Sequenom Delivers First Product for Epigenetics
Date:4/5/2011

IPSWICH, Mass. and SAN DIEGO, April 5, 2011 /PRNewswire/ -- New England Biolabs, Inc. (NEB) and Sequenom, Inc. (NASDAQ: SQNM) jointly announce that they have signed a licensing and co-marketing agreement to commercialize research tools for epigenetics. This agreement is the result of a research collaboration between the two companies that has culminated in the development of the EpiMark™ Methylated DNA Enrichment Kit from NEB.

(Logo: http://photos.prnewswire.com/prnh/20090921/NE79207LOGO-b)

The EpiMark Methylated DNA Enrichment Kit utilizes the innovative proprietary technology and intellectual property, methyl-CpG-immunoprecipitation (MCIp), acquired by Sequenom through an assignment of intellectual property rights from the University of Regensburg, Germany.  The MCIp technology is based on the work of Prof. Michael Rehli at the Department of Hematology and Oncology.  It is used to advance discovery and analysis of differentially methylated regions in biological samples, such as methylation differences between fetal and maternal chromosomes that can enable non-invasive prenatal diagnostics.

The EpiMark Methylated DNA Enrichment Kit incorporates the methyl-CpG binding domain of human MBD2, fused to the Fc tail of human IgG1.  When coupled to magnetic beads, this antibody-like protein enables purification of methylated CpG DNA with superior sensitivity, accuracy and speed. NEB has enabled and optimized large-scale, high purity manufacturing of the protein and developed a user-friendly kit for the research community.

NEB will also be Sequenom's first choice supplier if the technology should be utilized for prenatal diagnostic purposes in the future. Sequenom has retained all rights for diagnostic uses.

"Collaborations have always played an essential role in the development of innovative research tools at New England Biolabs,"
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SOURCE New England Biolabs
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