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Taste Receptors in the Gut Identified as New Target for Satiety and Glucose Regulation
Date:11/15/2013

SAN DIEGO, Nov. 15, 2013 /PRNewswire/ -- NaZura BioHealth today announced clinical study results indicating that activation of taste receptors in the lower gut can amplify the release of hormones involved in satiety and glucose regulation.  In an oral presentation to be made today at the Obesity Society's Annual Scientific Meeting, principal investigator Steven R. Smith, MD will describe how NaZura's proprietary Gut Sensory Modulation (GSM) technology can be used to intensify the body's natural, food-driven signals.

Delivering formulations of GRAS (Generally Recognized As Safe) dietary ingredients and FDA-approved food additives to the lower gut activates chemosensory sweet, umami and bitter receptors on enteroendocrine cells. These cells release a number of peptides including peptide YY (PYY), which signals satiety to the brain, and glucagon-like peptide-1 (GLP-1), which plays an important role in glucose regulation. The activation of taste receptors with non-nutritive agonists in effect stimulates the enteroendocrine cells to react as though a greater caloric load had been consumed. In short-term studies, NaZura has shown that formulations of sweet, umami and bitter agonists increased the body's food-driven production of PYY and GLP-1 twofold compared to placebo under various meal conditions.

"NaZura BioHealth has broken new ground with this concept of localized delivery of active compounds to the enteroendocrine cells with the goal of improving weight management and glucose control  " said Alain D. Baron, MD, president and chief executive officer of NaZura BioHealth. "As we're hearing at this week's Obesity Society meeting there remains a significant need for safe solutions to help people manage their weight."

NaZura BioHealth Poster at Obesity Society Annual Scientific Meeting

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SOURCE NaZura BioHealth
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