Navigation Links
Targeted Genetics Reports on Recombinant DNA Advisory Committee (RAC) Review of its Phase 1/2 Trial of tgAAC94 for Rheumatoid Arthritis
Date:9/17/2007

cal trial and scientific process determine the risks and potential of gene therapy before rushing to judgment and hampering the development of what could one day play a significant role in the treatment of serious diseases."

About Histoplasmosis

Histoplasmosis is a fungal infection resulting from exposure to spores of the microscopic fungus, Histoplasma capsulatum. Clinical manifestations can vary from a mild flu-like illness that may not produce any noticeable symptoms to rapidly progressive, sometimes fatal, disseminated disease. The degree of symptoms experienced from this infection can be highly variable depending on a number of factors including the relative strength of the infected person's immune system. Many of the medications commonly prescribed to patients undergoing treatment for inflammatory arthritis, including those that were being taken by the patient, are recognized to have immunosuppressant effects.

About tgAAC94 and the Phase I/II Study

tgAAC94 is being developed as a supplemental therapeutic to systemic anti-TNF-alpha protein therapy for use in patients with inflammatory arthritis who have one or more joints that do not fully respond to systemic protein therapy. The product candidate uses Targeted Genetics' recombinant AAV (rAAV) vector technology to deliver a DNA sequence that encodes a soluble form of the TNF-alpha receptor (TNFR: Fc). Soluble TNFR:Fc inhibits the immune stimulating activity of TNF-alpha. Direct injection of tgAAC94 into affected joints leads to the localized production of secreted TNFR:Fc within joint cells, reducing the activity of TNF-alpha within the joint and, potentially, leading to a decrease in the signs and symptoms of inflammatory disease and inhibition of joint destruction.

The Phase I/II study is designed to assess the safety and potential efficacy of different doses of tgAAC94 administered directly to affected joints of subjects with inflammatory arthritis. Subjects already enrolled in
'/>"/>

SOURCE Targeted Genetics Corporation
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy
2. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
3. Antisense Pharma: Promising Phase IIb Results of Targeted Therapy with AP 12009 in Recurrent Anaplastic Astrocytoma
4. Targeted Genetics Reports Inflammatory Arthritis Clinical Data at European Rheumatology Conference
5. Algeta Demonstrates Targeted Cancer-killing Potential of Novel Alpha Particle Linked Antibodies in Leading Medical Journal Blood
6. ApoCells Cancer Predictive Index Helps Oncologists Select the Most Effective Targeted Drug Therapy
7. News from the Battlefield of Metastatic Cancer: Epeius Biotechnologies Draws the Sword of Targeted Gene Delivery (Rexin-G) from the Stone of Chemistry and Physics
8. Data Show SuperGens Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51
9. Calando Pharmaceuticals Announces Preclinical Efficacy and Safety Data of Targeted, Systemic Delivery of siRNA at AACR Annual Meeting
10. Arrowhead Subsidiary, Calando Pharmaceuticals Publishes Study on Targeted, Systemic Delivery of siRNA
11. Calando Pharmaceuticals Publishes the First Non-Human Primate Study on Targeted, Systemic Delivery of siRNA in National Academy of Sciences Journal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 27, 2014 According to ... Radiology, CAD/CAM, Dental Chairs, Dental Lasers), Current Trends, Opportunities ... global Dental Equipment Market is expected to reach ... 2014, growing at a CAGR of 5.7% between ... data tables and 61 figures spread through 167 ...
(Date:8/27/2014)... Reportlinker.com announces that a new market ... Global Heart Valve Repair and Replacement Market ... About Heart Valve Repair and Replacement Heart ... control the flow of blood during the cardiac ... such as valvular stenosis, valvular insufficiency or regurgitation, ...
(Date:8/27/2014)... Aug. 27, 2014  Hill-Rom Holdings, Inc. (NYSE: ... management presentation at the Morgan Stanley Global Healthcare Conference ... You are invited to listen to the live ... or access it directly at http://cc.talkpoint.com/morg007/090814a_ac/?entity=26_7CLOGQP .  A ... hour after conclusion of the live event and accessible ...
Breaking Medicine Technology:Dental Equipment Market Worth $7,138.9 Million by 2019 2Dental Equipment Market Worth $7,138.9 Million by 2019 3Global Heart Valve Repair and Replacement Market 2014-2018 2Global Heart Valve Repair and Replacement Market 2014-2018 3Global Heart Valve Repair and Replacement Market 2014-2018 4
... provide first real-time analysis of such ... infectious-disease outbreaks, ... its kind, infectious-disease-modeling experts at Fred,Hutchinson Cancer Research Center confirm ... a small number of people within a family in,Indonesia. The ...
... Journal Nature Medicine, CLEVELAND, Aug. 27 ... mechanism that accounts for platelet hyper-responsiveness,during abnormal ... for fatal,heart attacks and strokes. In ... Podrez, M.D., Ph.D., of,Cleveland Clinic,s Lerner Research ...
Cached Medicine Technology:Study Confirms Limited Human-To-Human Spread of Avian-Flu Virus in Indonesia in 2006 2Study Confirms Limited Human-To-Human Spread of Avian-Flu Virus in Indonesia in 2006 3Study Confirms Limited Human-To-Human Spread of Avian-Flu Virus in Indonesia in 2006 4Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation 2Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation 3
(Date:8/27/2014)... August 27, 2014 As medical marijuana ... big business has taken notice. With 23 states and ... cannabis friendly legislation on their books the time for ... as New York and Florida are in the process ... laws a void of reliable information and services has ...
(Date:8/27/2014)... Chicago, Illinois (PRWEB) August 27, 2014 ... the 2014 FIBA World Cup in Spain at ... in their role as FIBA Equipment & Venue Centre Partner ... to 2016. , The six courts will bear the Connor ... by fans around the globe on the ESPN broadcasts of ...
(Date:8/27/2014)... Ontario (PRWEB) August 27, 2014 When Jagger ... a call from his mother; one that he credits as ... received. His mom had news that she could set him ... supporting people with disabilities. Jagger took that job, and he ... disabled. Throughout these past two decades, he also worked in ...
(Date:8/27/2014)... Overconfident people are better at convincing others that they,re ... more likely to get promotions and reach high-level positions, ... these "self-deceived" people are also more likely to overestimate ... And finally, people who underestimate themselves are regarded as ... researchers. Their findings were published Aug. 27 in the ...
(Date:8/27/2014)... CarePoint Health is proud to ... has joined our network, CarePoint Health Medical Group. ... Oko, Dr. Yanina Meshko and Dr. Nana Yenukashvili ... experienced physicians comprise CarePoint Health Medical Group, a ... Hudson County, representing a wide range of specialties. ...
Breaking Medicine News(10 mins):Health News:The Marijuana Real Estate Market Opens Up 2Health News:The Marijuana Real Estate Market Opens Up 3Health News:Connor Sports® Provides Six Custom Courts for 2014 FIBA World Cup - Time-Lapse Video of FIBA Courts Production Released 2Health News:Connor Sports® Provides Six Custom Courts for 2014 FIBA World Cup - Time-Lapse Video of FIBA Courts Production Released 3Health News:Fitness on the Go Expands into Liberty Village, City Place and Harbourfront Communities 2Health News:Fitness on the Go Expands into Liberty Village, City Place and Harbourfront Communities 3Health News:Fitness on the Go Expands into Liberty Village, City Place and Harbourfront Communities 4Health News:Overconfident Folks May Blind Others to Their Real Abilities 2Health News:Hoboken Pediatrics Joins CarePoint Health Medical Group 2Health News:Hoboken Pediatrics Joins CarePoint Health Medical Group 3
... USA, the leading generic pharmaceutical company, today released ... part of the "Year of Affordable Healthcare" campaign.The ... www.yearofaffordablehealth.com/gallery ) is meant to illustrate the important ... since the passage of Waxman-Hatch 25 years ago. ...
... Texas, Feb. 24 The Texas Association of Health,Underwriters ... the Capitol on,March 2, 2009 at the Sheraton Hotel ... to network and discuss client issues with other agents,and ... a panel discussion featuring political blogger from,InThePinkTaxas.com and editor ...
... recent weeks, a number of childhood deaths across the country ... importance of preventing this serious and sometimes deadly disease with ... influenza activity at a relatively high level across the country, ... the vaccine to do so. It takes about two weeks ...
... BEACH, Fla., Feb. 24 Today Sentry Data ... Platform to independent solution providers. The Datanex(TM) ... that allows solution providers to construct rich healthcare ... the world,s fastest and most comprehensive healthcare data ...
... Feb. 24 Solos Endoscopy, Inc. (Pink Sheets: ... Breast Endoscopy System, the MammoView(TM), was featured in ... in the January 2009 issue. The article focused ... detect breast cancer earlier, with minimally invasive ductoscopy. ...
... After a successful showing at the 2009,South Beach ... it,has officially hit over 300 stores in South Florida ... the recently opened accounts include: CVS on Lincoln Road,Miami ... Palm Beach;,Presidente Markets, Tom Thumb, Penn Dutch, Quick Stop, ...
Cached Medicine News:Health News:Texas Association of Health Underwriters Announces 15th Annual Day at the Capitol 2Health News:Recently Reported Childhood Deaths from Influenza Are a Stark Reminder to Vaccinate Now 2Health News:Sentry Data Systems Announces Interoperative Healthcare Cloud Computing Platform 2Health News:Sentry Data Systems Announces Interoperative Healthcare Cloud Computing Platform 3Health News:Solos Endoscopy, Inc.'s Breast Endoscopy System Featured in January Issue of Outpatient Surgery Magazine 2Health News:Next Generation Waters Successfully Reaches Over 300 Stores! 2
Standard Deflectable Catheters...
Standard Deflectable Catheters...
... wide range of fixed curve catheters designed ... children and other patients with small anatomies. ... using only the finest materials. A unique ... and extrusion technologies results in the excellent ...
... offers a wide range of fixed curve ... needs of children and other patients with ... demanding specifications using only the finest materials. ... wire braiding and extrusion technologies results in ...
Medicine Products: