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Tapestry Pharmaceuticals Presents Data on TPI 287 at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
Date:10/23/2007

BOULDER, Colo., Oct. 23 /PRNewswire-FirstCall/ -- Tapestry Pharmaceuticals, Inc. (Nasdaq: TPPH), is presenting data today at the AACR- NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. This year's conference is being held October 22-26, 2007 at the Moscone Convention Center, San Francisco, Calif.

In a poster session, Tapestry investigators will be discussing data from preclinical studies of TPI 287, the company's proprietary next-generation taxane for the treatment of multiple cancer indications, on Tuesday, October 23, 2007 from 12:30 - 2:30 PM Pacific Time in the Drug Resistance Session A:

Poster #192: "TPI 287, A Next Generation Taxane Derivative, Functionally

Modulates MDR1 P-glycoprotein Drug Transport Pump and is Active in

Resistant Tumor Cells"

The poster outlines a number of different assays confirming Tapestry's observation that its lead drug candidate TPI 287 is less sensitive in a variety of cancer cell lines to MDR1 mediated efflux than other approved taxanes. MDR1 mediated drug efflux may be a primary cause of resistance to chemotherapy with taxanes.

Additionally, TPI 287 is retained at higher levels in MDR1 expressing cell lines than either paclitaxel or IDN 5109, another taxane in development purported to be active in MDR1 expressing tumors. In addition, TPI 287 has demonstrated tumor growth inhibition when delivered orally in subcutaneous mouse xenograft models of both pancreatic cancer and glioblastoma multiforme (GBM). Tapestry has Phase 2 studies underway for TPI 287 in pancreatic and prostate cancer. The Company plans to evaluate TPI 287 in a Phase 2 study in GBM. A copy of the poster is available on Tapestry's website at '/>"/>

SOURCE Tapestry Pharmaceuticals, Inc.
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