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Tapestry Initiates Phase 2 Trial of TPI 287 for the Treatment of Advanced Pancreatic Cancer
Date:10/3/2007

efined by RECIST criteria), decreases in CA 19-9 (a tumor marker in some patients with pancreatic cancer), and the overall duration of response in those patients achieving a response. In addition, amelioration of pain and reduction in analgesic use will be quantified as another measure of clinical benefit.

Patients will remain on study until tumor progression or death, unacceptable toxicity, withdrawal of consent or discontinuation based upon investigator discretion. Patients will be followed for survival for up to one year after enrollment in the study.

"We are structuring a diversified Phase 2 program for TPI 287 that will allow us to effectively evaluate this unique taxane as a treatment option for patients who have failed other therapeutic regimens," commented Dr. Sandra Silberman, chief medical officer of Tapestry Pharmaceuticals. "Our primary goal in this study is to rigorously explore the activity of TPI 287 in patients with advanced pancreatic cancer who have failed first line therapy. We are also interested in building more experience with this compound in the clinic, defining its safety and side-effect profile and tracking its impact on the quality of patients' lives, particularly as it relates to pain and pain management."

Clinical Program for TPI 287

In addition to the dosing of the first patient in this Phase 2 advanced pancreatic cancer trial and the on-going Phase 2 clinical trial in patients with advanced, hormone refractory prostate cancer, the Company may begin a third Phase 2 clinical trial in patients with glioblastoma multiforme, a primary cancer of the central nervous system. In all of these Phase 2 studies, TPI 287 will be administered as an intravenous dosage form.

In parallel to these Phase 2 studies, the company plans to initiate a Phase 1b study evaluating the oral bioavailability of TPI 287. In 2008, assuming feasibility of oral dosing from this study, the company may initiate a Phase 1b/2 study of the combin
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SOURCE Tapestry Pharmaceuticals, Inc.
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