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Talecris Biotherapeutics Launches PROLASTIN®-C in Canada
Date:11/2/2010

RESEARCH TRIANGLE PARK, N.C., Nov. 2, 2010 /PRNewswire/ -- Talecris Biotherapeutics (Nasdaq: TLCR) announced today the Canadian launch of PROLASTIN®-C (Alpha1-Proteinase Inhibitor [Human])(A1PI), a more concentrated and purified formulation of PROLASTIN®, the only approved alpha1-augmentation therapy in Canada for more than 20 years.  PROLASTIN-C delivers twice the active protein per milliliter as PROLASTIN, cutting the infusion volume and time in half when given at the recommended rate of 0.08 mL/kg/min. 

PROLASTIN-C has replaced PROLASTIN in Canada. Both products are indicated for chronic augmentation and maintenance therapy in adults who have emphysema due to a genetic condition known as alpha1-antitrypsin (AAT) deficiency. The active protein in PROLASTIN-C increases or "augments" protein levels in AAT-deficient patients.

"Talecris research and development scientists continually strive to enhance the overall quality of our products by incorporating the latest advances in technology," said Joel Abelson, Senior Vice President & General Manager, Portfolio Management & International Business. "PROLASTIN-C is an example of our commitment to supporting patients who use protein therapies to treat their rare and life-threatening conditions."

PROLASTIN-C contains the same active ingredient as PROLASTIN. Clinical studies demonstrated that the products are equally effective at raising alpha1 levels, and that PROLASTIN-C has an adverse event profile consistent with that of PROLASTIN.  (http://www.biomedcentral.com/1472-6904/10/13

The most common drug-related adverse reactions during clinical trials in >/=1% of subjects were chills, malaise, headache, rash, hot flush, and pruritus. The most serious adverse reaction observed during clinical studies with PRO
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