Navigation Links
Taking a Predictive Approach to Identifying Adverse Drug Reactions
Date:12/21/2011

BOSTON, Dec. 21, 2011 /PRNewswire-USNewswire/ -- In a move aimed at bolstering current systems for assessing and monitoring drug safety, researchers at Children's Hospital Boston have created a new method that combines multiple forms of widely available data to predict adverse drug reactions. Unlike current approaches, which rely on detecting evidence of drug safety issues as they accumulate over time in clinical databases, this new method may be able to identify issues years in advance.

This study, led by Aurel Cami, Ph.D., and Ben Reis, Ph.D., of Children's Hospital Boston's Informatics Program (CHIP), appeared online December 21 in Science Translational Medicine.

The safety of drugs in the market is currently assessed through a combination of adverse drug event (ADE) reporting and data mining tools designed to detect previously unrecognized drug-ADEs relationships. While generally effective, these methods may not be able to flag the presence of certain types of ADEs until patients have been on the drug for some time.

Because of these limitations, it can take years before physicians and regulators accumulate enough data to recognize serious safety problems with a particular drug and take appropriate action.

To help address these delays and the public health risks associated with them, Reis and Cami set out to create a mathematical model for predicting drug-ADE relationships that might likely appear within a few years of a drug's entry into the market.

"This approach allows us to make the important transition from detection to prediction," said Reis, who leads the Predictive Medicine Group within CHIP. "We can potentially identify a dangerous drug side effect early on, instead of having to wait for sufficiently many patients to be affected by it in order to allow for detection."

"Given the myriad of entities and complex relationships that exist in the pharmacological domain, we felt that a network-based ap
'/>"/>

SOURCE Children's Hospital Boston
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Huge Drop in Preterm Birth-Risk Among Women Taking Folic Acid One Year Before Conception
2. Type 2 Diabetes Patients Taking Exenatide Once Weekly, a Phase 3 Investigational Diabetes Therapy, Showed Improvements in Glycemic Control, Weight
3. After One Year, Type 2 Diabetes Patients Taking Exenatide Once Weekly Sustained Improvements in Glycemic Control and Weight; DURATION-1 Presented at ADA 2008
4. Patients Taking Cymbalta(R) Reported Reduced Pain Severity of Osteoarthritis of the Knee in New Study
5. New Studies Show Popular Heartburn Medications Moderate the Effect of Taking Widely Prescribed Heart Drug
6. Taking Folic Acid for a Year Before Pregnancy May Reduce Risk of Preterm Birth
7. Taking a Hard-Line Approach to Cardiovascular Risks in the Diabetes Patient
8. Study Results Present Efficacy and Safety Findings from the PHIRST-1 Study of Patients with Pulmonary Arterial Hypertension Taking Tadalafil Tablets Once Daily
9. Is Your Hair Taking a Break?
10. HealthCare Partners, IPA, Dr. Richard Merkin, CEO, Recognize Seniors Taking Their Healthcare Concerns Directly to Lawmakers in Washington, DC
11. Patients Taking VIMOVO(TM) Showed a Decrease in Incidence of NSAID-Associated Ulcers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... , Sept. 15, 2014 Research and ... Worldwide Market for In Vitro Diagnostic Tests, 9th Edition" ... covers the entirety of the clinical testing market and all ... Used by Top IVD Companies For Business Planning. ... based on the market events of 2013 and early 2014. ...
(Date:9/15/2014)... , Sept. 15, 2014 Biomerics ... the medical device market, announced its merger with ... Advanced Catheter Division. The new division was formed to ... device solutions for the structure heart, interventional radiology, ... Biomerics Advanced Catheter will be led by ...
(Date:9/15/2014)... , Sept. 15, 2014  MedExpress Urgent Care, a ... is now offering flu shots for ages four and up ... advising patients to get their flu shot early. ... at the end of June, making late summer and early ... flu season. MedExpress Vice President of Provider and Clinical Quality, ...
Breaking Medicine Technology:The Worldwide Market for In Vitro Diagnostic Tests, 9th Edition 2The Worldwide Market for In Vitro Diagnostic Tests, 9th Edition 3Biomerics and Access Point Technologies OEM Announce Merger and Creation of Biomerics Advanced Catheter Division 2MedExpress Quotes Late Summer, Early Fall As Best Time to Receive Flu Shot 2
... Since the 1950s, the American,Heart Association (AHA) ... take,antibiotics before having dental work or other procedures ... were supposed to prevent,infective endocarditis, a potentially serious ... the latest evidence, the AHA now emphasizes routine,oral ...
... Board Recommends Continuing Study, NEW YORK, Oct. ... announced today the completion of interim analysis of ... drug candidate,pafuramidine. An independent Data Safety Monitoring Board ... trial should continue as,planned. The trial is evaluating ...
Cached Medicine Technology:For Most, Good Oral Care Does More Than Antibiotics to Prevent Dental-Related Heart Problems, Reports the Harvard Heart Letter 2Immtech Announces Interim Analysis in Phase III African Sleeping Sickness Trial 2Immtech Announces Interim Analysis in Phase III African Sleeping Sickness Trial 3Immtech Announces Interim Analysis in Phase III African Sleeping Sickness Trial 4
(Date:9/15/2014)... The Best Hospitals Honor Roll ... of seven hospitals using OnBase as their enterprise ... Clinic were ranked at the top of the list, ... cover nearly 5,000 medical centers across the country with ... scored highest in at least six of the sixteen ...
(Date:9/15/2014)... Dotinga HealthDay Reporter , ... cholesterol-lowering drugs are more likely to fill their prescriptions ... generic brands, new research suggests. At issue are ... Crestor, Zocor and Lipitor. Generic statins are also available. ... heart problems due to clogged arteries. About ...
(Date:9/15/2014)... The White House has recently begun shifting ... jail and prison and toward helping them access addiction ... positive change. , The nation is currently grappling with ... to an article from The Washington Post , ... away from using the criminal justice system to address ...
(Date:9/15/2014)... Dennis Thompson ... News) -- The severe respiratory virus believed to have ... states has now spread to the Northeast, health officials ... confirmed on Friday more than a dozen cases of ... for children with asthma. And on Saturday, the ...
(Date:9/15/2014)... Array Health , an independent ... that Independence Blue Cross (Independence), the ... selected the Array Spectrum™ Private Exchange solution for ... employers with more than 100 employees. Using the ... offer employer groups a comprehensive selection of products ...
Breaking Medicine News(10 mins):Health News:Seven of Top Ten Hospitals in the U.S. Leverage OnBase by Hyland ECM Solution 2Health News:Older Patients More Likely to Fill Prescriptions for Generic Statins: Study 2Health News:Older Patients More Likely to Fill Prescriptions for Generic Statins: Study 3Health News:White House Shifts Policy on Drugs 2Health News:Kids' Severe Respiratory Virus Confirmed in Northeast 2Health News:Kids' Severe Respiratory Virus Confirmed in Northeast 3Health News:Independence Blue Cross Selects Array Spectrum™ Private Health Insurance Exchange Technology 2Health News:Independence Blue Cross Selects Array Spectrum™ Private Health Insurance Exchange Technology 3
... to press ahead or wait; job creation is public,s top ... of Americans want some kind of health reform in the ... a good thing if the legislation proposed by the Democrats ... if health reform would be good or bad for the ...
... , , FAIRFIELD, N.J. , Feb. 11 ... without the right footwear. And the actual surface for the ... Athletic™ lineup of portable fitness mats and interlocking gym flooring ... basic stretching, Shock Athletic products offer a broad range of ...
... , ... a lawyer with the Louthian Law Firm in Columbia, S.C., says developments in lawsuits ... cannot seek justice. , ... Columbia, South Carolina (PRWEB) February 11, 2010 -- The anti-smoking patch Chantix continues ...
... ... panic as the long-term shortage of Armour Thyroid, Nature-Throid, and Westhroid continues. The ... is a little-known secret that thousands of Americans have already discovered. There is ... ...
... ... Humber NHS Framework, in addition to two in Dec & Jan, with Acute & Mental ... , ... 11, 2010 -- BigHand, a leading provider of voice technology to the healthcare market, has ...
... , DENVER, CO , Feb. 10 ... ( MIT ) is pleased to announce that its ... the production certification to produce Med-Jet products in China ... subject of a recent visit by the SFDA. These facilities ...
Cached Medicine News:Health News:Poll Shows Eroding Support for Health Reform 2Health News:Poll Shows Eroding Support for Health Reform 3Health News:Poll Shows Eroding Support for Health Reform 4Health News:For a Healthier, Cleaner Fitness Regimen - Venture Products' Shock Athletic(TM) Mats and Interlocking Flooring 2Health News:For a Healthier, Cleaner Fitness Regimen - Venture Products' Shock Athletic(TM) Mats and Interlocking Flooring 3Health News:South Carolina Attorney Says Legal Options Still Available To Those Harmed By Chantix 2Health News:South Carolina Attorney Says Legal Options Still Available To Those Harmed By Chantix 3Health News:No End In Sight To The Armour Thyroid Shortage? 2Health News:No End In Sight To The Armour Thyroid Shortage? 3Health News:Three NHS Trusts Choose BigHand Voice Technology Under YHCPC Framework Agreement 2Health News:Major milestone achieved by our joint venture in China 2Health News:Major milestone achieved by our joint venture in China 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: