Navigation Links
Takeda Submits New Drug Application in the U.S. for Azilsartan Medoxomil Plus Chlorthalidone, an Investigational Fixed-Dose Combination for the Treatment of Hypertension
Date:2/23/2011

DEERFIELD, Ill. and OSAKA, Japan, February 23, 2011 /PRNewswire/ -- Takeda Pharmaceutical Company Limited (Takeda) announced today that Takeda Global Research & Development Center, Inc. U.S., submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for an investigational fixed-dose combination of azilsartan medoxomil plus chlorthalidone (CLD) for the treatment of hypertension, or high blood pressure. Discovered by Takeda, azilsartan medoxomil is an angiotensin II receptor blocker (ARB) that lowers blood pressure by blocking the action of angiotensin II, a vasopressor hormone. Chlorthalidone is a long-acting oral thiazide-like diuretic used in the treatment of hypertension. The NDA submission was supported by four phase 3 clinical trials involving more than 4,000 patients with hypertension.

“Millions of patients with hypertension do not have their condition under control,” said Darryl Sleep, M.D., vice president, clinical science, Takeda Global Research & Development Center, Inc. U.S. “We believe this compound, the first in the U.S. to combine an ARB with chlorthalidone, could potentially provide an important new treatment option for patients with hypertension and the health care providers who manage them.”

In a phase 3 clinical trial, azilsartan medoxomil (20 mg/day, 40 mg/day and 80 mg/day), combined in a fixed-dose with CLD (12.5 mg/day and 25 mg/day), was studied versus azilsartan medoxomil and CLD monotherapies. In other studies, the fixed-dose combination of azilsartan medoxomil plus CLD was compared to azilsartan medoxomil coadministered with hydrochlorothiazide (HCTZ), another diuretic, and with a fixed-dose combination of olmesartan medoxomil and HCTZ.

Results from a phase 3 clinical trial of the fixed-dose combination of azilsartan medoxomil plus CLD were previously presented at the American Society of Hypertension, Inc. (ASH), 25th Annual Scientific Meeting and Expositio
'/>"/>

SOURCE Takeda Global Research & Development Center, Inc., U.S.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Takeda Enters Into Global Strategic Partnerships With Covance and Quintiles
2. Takeda Completes Settlements With All Defendants in U.S. Patent Litigation Involving ACTOS® (pioglitazone HCI), ACTOplus met® (pioglitazone HCl and metformin HCl) and duetact® (pioglitazone HCl and glimepiride)
3. Takeda Responds to Announcement about Suspension of Rosiglitazone Marketing Authorization in Europe and Restrictions in the U.S.
4. Arthritis Foundation and Takeda Launch First-Ever National Gout Public Service Announcement (PSA) Campaign, Urging People Living With Gout to Keep Enjoying Lifes Simple Pleasures
5. Orexigen® Therapeutics and Takeda Enter Into Partnership to Commercialize Contrave® in North America
6. Takeda Responds to FDA Advisory Committee Recommendation
7. Takeda Provides Update on Patent Litigation for ACTOS(R) (pioglitazone HCl) and ACTOplus met(R) (pioglitazone HCl and metformin HCl) in the U.S.
8. CellCentric Licenses Novel Epigenetic Discovery Programme to Takeda
9. Amylin and Takeda Announce Decision to Advance Development of Pramlintide/Metreleptin Combination Treatment for Obesity
10. Takeda Announces Initiation of Trial to Study the Concomitant Use of Dexlansoprazole and Other Proton Pump Inhibitors with Plavix(R) (clopidogrel bisulfate)
11. Emerging Agents from Theravance/Astellas, Johnson & Johnson/Basilea and Forest/Astrazeneca/Takeda Will Drive Modest Growth in the MRSA Drug Market Through 2018
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... May 6, 2015  Membership in Medicare Supplement plans ... Healthcare Business Strategy report released by Mark Farrah ... Medigap or Med Supp plans, covered approximately 11.2 ... 5.2% increase from 2013. Between 2013 and 2014, ... covered lives.  Though UnitedHealth was the segment growth ...
(Date:5/6/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/jskhnb/energy_based ) has announced ... Global Strategic Business Report" report to their offering. ... Canada , Japan , ... and Rest of World. Annual estimates and forecasts are provided ... analysis is provided for these markets. The global ...
(Date:5/6/2015)...   CEFALY Technology , the creators of the ... for use prior to the onset of migraine pain, ... at the EUROHEADPAIN - Midterm Meeting at the International ... , from May 14-17, 2015. On May ... major European research project focused on migraines, CEFALY ...
Breaking Medicine Technology:Continued Growth in Med Supp Market for 2014 according to Mark Farrah Associates 2Energy based Ablation Devices - Global Strategic Business Report 2015: Increasing Incidence of Cancer Bodes Well For Energy Based Ablation Devices 2Energy based Ablation Devices - Global Strategic Business Report 2015: Increasing Incidence of Cancer Bodes Well For Energy Based Ablation Devices 3CEFALY to Present Breakthrough Data in Migraine Treatment at International Headache Society Congress 2
... LOUIS, Oct. 25, 2011 Stereotaxis, Inc. (NASDAQ: ... results for the third quarter ended September 30, 2011 on ... financial markets.  The Company will host a conference call and ... Time to discuss the Company,s third quarter results and corporate ...
... some newly-developed bio-pharmaceutical products thrive upon launch, many more ... In order to differentiate the treatment benefits of ... and scientific thought leaders, targeting and engaging those who ... in the medical community. In fact, according ...
Cached Medicine Technology:Stereotaxis to Report Third Quarter 2011 Financial Results and Conduct Conference Call on November 7, 2011 2Stereotaxis to Report Third Quarter 2011 Financial Results and Conduct Conference Call on November 7, 2011 3Latest Pharmaceutical Launch Strategies Demonstrate Growing Importance of Thought Leader Engagement at Market Entry 2
(Date:5/6/2015)... (PRWEB) May 06, 2015 Anitha Nallari, ... Hematology Oncology Consultants, Inc. in Columbus, OH. Dr. ... has a special focus in breast cancer, lung cancer, GI ... lymphoma as well as benign hematology. , Dr. ... internal medicine by the American Board of Internal Medicine. She ...
(Date:5/6/2015)... May 06, 2015 Vancouver Chiropractic ... shared their new blog containing the Canadian Physical ... the Canadian Society for Exercise Physiology (CSEP). Since ... activity, health and fitness research and personal training ... exercise are highly beneficial and a rich resource ...
(Date:5/6/2015)... May 06, 2015 Follow us ... are increasing, driven by the rising consumer awareness over ... of contagious diseases. Hand washing is becoming a part ... apprehension over contracting infections. Periodic outbreak of Avian flu, ... Ebola virus disease (EVD) epidemic in West ...
(Date:5/6/2015)... HOUSTON, TX (PRWEB) May 06, 2015 ... the 1,000 user mark after launching in mid-February. The ... qualified candidates who have previous experience in the industry. ... their profession. , According to Kyle Johnson, CTO, unique ... compared to the first month: "Each new job posting ...
(Date:5/6/2015)... TU-Automotive has opened press registration for TU-Automotive Detroit as ... the headlines of major publications world-wide. With 150+ speakers ... ready to share their visions for the future of ... press to go behind the scenes and hear major ... “This year we’re releasing a preview of all the ...
Breaking Medicine News(10 mins):Health News:New Oncologist to Join Hematology Oncology Consultants, Inc. 2Health News:New Oncologist to Join Hematology Oncology Consultants, Inc. 3Health News:Vancouver Chiropractor Shares Canadian Physical Activity and Sedentary Behavior Guidelines by CSEP in New Blog 2Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 2Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 3Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 4Health News:Job Seekers Turn to JobMedic to Find Healthcare Positions - JobMedic.com Reaches 1,000 User Milestone 2Health News:Press Registration for TU-Automotive Detroit Now Open 2
... by researchers at the Johns Hopkins Bloomberg School of ... tactics to ward off bacterial// pathogens and plasmodium parasites. ... with the proteins in the immune system of mosquitoes. ... involved in limiting infection by the malaria parasites were ...
... conducted by the researchers at the University of Michigan ... in increased stress among adults. // Disaster such as ... 30-40 % of post-traumatic stress disorder among adults. In ... percent of the general population may experience PTSD symptoms, ...
... for implementation of supplementary nutrition scheme by training the Self ... anganwadis from the NGOs in the national capital. ... C K Thakker vacated its May 12 order by which ... to the apex court order that no contractors would be ...
... Justifying the proposed 27 per cent OBC quota in ... said that the anti-reservation agitation was a media creation ... accordance with the Constitution. ,'The resistance was ... ,Stating that all political parties had supported the government ...
... to suffer from cancer and die from it, researchers say. ... //Haifa University suspect that cancers are most likely caused by ... ,The researchers looked at the incidence and death rate ... - comparing those who emigrated from Europe before 1939 with ...
... to reattach the foot of a four-year-old boy. The boy had ... // riding over him on a lawn mover. ,According ... lawn mower when the boy came up unexpectedly behind him. Constable ... reverse and accidentally ran over the boy's leg. It was explained ...
Cached Medicine News:Health News:What Ticks the Mosquito immune system? 2Health News:PTST Mostly Seen Among Disaster Victims 2
Each handle is designed to fit a specific trephine size. For use in performing free-hand uniform donor buttons....
Each handle is designed to fit a specific trephine size. For use in performing free-hand uniform donor buttons....
Each handle is designed to fit a specific trephine size. For use in performing free-hand uniform donor buttons....
Each handle is designed to fit a specific trephine size. For use in performing free-hand uniform donor buttons....
Medicine Products: