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Takeda Submits New Drug Application for Alogliptin (SYR-322) in the U.S.
Date:1/3/2008

ment option for patients with type 2 diabetes and the healthcare providers who treat them."

GLP-1 and GIP are produced by the digestive tract in response to food, and regulate glucose balance, primarily by stimulating glucose-dependent insulin secretion. In addition, GLP-1 suppresses pancreatic glucagon secretion and subsequent liver glucose production, enhances glucose disposal, slows gastric emptying, and elicits satiety, a feeling of fullness.

About Type 2 Diabetes

Type 2 diabetes has reached epidemic proportions in the United States with almost 20 million people currently living with the disease. A progressive disease, type 2 diabetes requires continued monitoring by a physician and patients are often required to take multiple medications at any time-in addition to diet and exercise-in order to maintain glucose control. There are two primary defects associated with type 2 diabetes: the body does not efficiently use the insulin it produces -- insulin resistance -- and/or it does not produce enough insulin-insulin deficiency. DPP-4 inhibitors offer a new way to treat insulin deficiency and have the potential to improve pancreatic beta-cell function.

About Takeda's Commitment to Type 2 Diabetes

Takeda has a long-standing tradition of striving toward better health for people living with type 2 diabetes by developing innovative pharmaceutical solutions to help manage their condition. In 1999, Takeda launched ACTOS(R) (pioglitazone HCl) -- an insulin sensitizer which today is available globally -- followed in recent years by the introduction of the ACTOS family of products, with more than 75 million prescriptions written, covering more than 8.5 million patients and 4.5 million patient years.

Over the past decade, Takeda has furthered their commitment to people living with type 2 diabetes and pursued the development of alogliptin, an investigational DPP-4 inhibitor. ACTOS and alogliptin have distinct but complementary mechanism
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SOURCE Takeda Global Research & Development Center, Inc.
Copyright©2008 PR Newswire.
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