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Takeda Provides Update on Patent Litigation for ACTOS(R) (pioglitazone HCl) and ACTOplus met(R) (pioglitazone HCl and metformin HCl) in the U.S.
Date:4/28/2010

nusual tiredness, loss of appetite, dark urine, or yellowing of the skin or eyes. If a patient is of childbearing age, they should talk to their doctor before taking ACTOplus met, as it could increase their chance of becoming pregnant. A patient should talk to their doctor if they are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed.

ACTOplus met may cause low blood sugar. Lightheadedness, shakiness, dizziness, or hunger may indicate low blood sugar. Patients who experience low blood sugar should talk to their doctor.

Some people taking ACTOplus met may experience flulike symptoms, mild to moderate swelling of legs and ankles, anemia, and weight gain. Patients with diabetes should have regular eye exams. If a patient experiences vision problems, they should consult their doctor immediately.  Some patients have experienced visual changes while taking ACTOplus met. Some people, particularly women, are at higher risk of having bone fractures while taking pioglitazone. Other side effects may include cold-like symptoms, diarrhea, nausea, headache, urinary tract infection, dizziness, sinus infection, and anemia.

Individuals are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For Complete Prescribing Information, including warnings about heart failure and lactic acidosis and Medication Guide, please visit '/>"/>

SOURCE Takeda Pharmaceutical Company Limited
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