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Takeda Drives Leading PAMES Study in Brazil Showing Improved Symptom Relief for People with Erosive Gastroesophageal Reflux Disease (GERD)
Date:12/12/2013

ef for people with erosive GERD, not only here in Brazil, but in countries all around the world."

Results from the multicenter (14 Brazilian sites in 9 cities), double-blinded, randomized, parallel-group study comparing pantoprazole magnesium 40 mg (Tecta®) and esomeprazole 40 mg once daily in 578 patients with erosive GERD were:

  • Complete remission occurred in 61% of patients in each treatment group at 4 weeks (primary endpoint) and in 81% and 79% of patients in the pantoprazole magnesium and esomeprazole groups at 8 weeks, respectively.[1]
  • At 8 weeks, symptom relief rates with pantoprazole magnesium were significantly higher than that with esomeprazole (91.6% vs. 86%, P = 0.0370).[1]
  • Mucosal healing rates were high and not significantly different between treatments groups.[1]

The PAMES study has received continued recognition around the world in 2013 following presentation of results at three of the largest global congresses for digestive diseases; Digestive Disease Week (DDW), World Congress of Gastroenterology (WCOG) and United European Gastroenterology Week (UEGW).[3],[4],[5]

About GERD

Gastroesophageal reflux disease (GERD) or acid reflux disease (ARD), sometimes referred to as heartburn as it is the most common symptom of GERD, is a condition that develops when reflux of stomach contents causes troublesome symptoms or complications.[2]

GERD can be further classified as the presence of symptoms without erosions on endoscopic examination (non-erosive disease or NERD) or GERD symptoms with erosions present (ERD).[6] This latter presentation is also known as erosive esophagitis (EE).[6'/>"/>

SOURCE Takeda Pharmaceuticals International GmbH
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