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Takeda Completes Settlements With All Defendants in U.S. Patent Litigation Involving ACTOS® (pioglitazone HCI), ACTOplus met® (pioglitazone HCl and metformin HCl) and duetact® (pioglitazone HCl and glimepiride)
Date:12/21/2010

ioglitazone HCl and metformin HCl), ACTOplus met® XR (pioglitazone HCl and extended-release metformin HCl), and duetact® (pioglitazone HCl and glimepiride) are prescription medications used with diet and exercise to improve blood sugar (glucose) control in adults (greater than or equal to 18 years of age) with type 2 diabetes.

Important Safety Information

Warnings

ACTOS, ACTOplus met, ACTOplus met XR, and duetact are not for everyone. Certain patients with heart failure should not start taking ACTOS, ACTOplus met, ACTOplus met XR, or duetact. These medications can cause new, or worsen, heart failure. Patients should talk to their doctor immediately if they experience unusually fast weight gain, fluid retention (swelling), shortness of breath, unusual tiredness, or slow heartbeat.

Warnings Specific to ACTOplus met and ACTOplus met XR

Metformin, one of the medicines in ACTOplus met and ACTOplus met XR, can cause a rare but serious condition called lactic acidosis (a buildup of an acid in the blood) that can cause death. Lactic acidosis is a medical emergency and must be treated in the hospital. Because lactic acidosis occurs most frequently in people with kidney problems, ACTOplus met and ACTOplus met XR should not be used in people with kidney disease or in people 80 years of age or older whose kidneys do not work properly.

ACTOplus met and ACTOplus met XR should not be taken by people with metabolic acidosis or who drink excessive amounts of alcohol.

Patients should talk to their doctor if they are going to have an X-ray procedure using injectable dye and ar
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SOURCE Takeda Pharmaceuticals North America, Inc.
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